ENSMUSG00000038451


Mus musculus

Features
Gene ID: ENSMUSG00000038451
  
Biological name :Spsb2
  
Synonyms : O88838 / SPRY domain-containing SOCS box protein 2 / Spsb2
  
Possible biological names infered from orthology : Q99619 / splA/ryanodine receptor domain and SOCS box containing 2
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 124808661
Gene end: 124810619
  
Corresponding Affymetrix probe sets: 10541721 (MoGene1.0st)   1422106_a_at (Mouse Genome 430 2.0 Array)   1451585_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041585
Ensembl peptide - ENSMUSP00000108092
Ensembl peptide - ENSMUSP00000118347
Ensembl peptide - ENSMUSP00000122149
Ensembl peptide - ENSMUSP00000060124
NCBI entrez gene - 14794     See in Manteia.
MGI - MGI:1315199
RefSeq - XM_006505567
RefSeq - NM_001306050
RefSeq - NM_001306051
RefSeq - NM_001306052
RefSeq - NM_001306053
RefSeq - NM_013539
RefSeq - XM_006505565
RefSeq - XM_006505566
RefSeq Peptide - NP_001292979
RefSeq Peptide - NP_001292982
RefSeq Peptide - NP_038567
RefSeq Peptide - NP_001292980
RefSeq Peptide - NP_001292981
swissprot - D3Z7N7
swissprot - D3YX10
swissprot - O88838
Ensembl - ENSMUSG00000038451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-228j22.2ENSDARG00000088985Danio rerio
 SPSB2ENSG00000111671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spsb4 / Q8R5B6 / SPRY domain-containing SOCS box protein 4 / Q96A44* / splA/ryanodine receptor domain and SOCS box containing 4*ENSMUSG0000004699752
Spsb1 / Q9D5L7 / SPRY domain-containing SOCS box protein 1 / Q96BD6* / splA/ryanodine receptor domain and SOCS box containing 1*ENSMUSG0000003991151
Fbxo45 / Q8K3B1 / F-box/SPRY domain-containing protein 1 / P0C2W1* / F-box protein 45*ENSMUSG0000003576430


Protein motifs (from Interpro)
Interpro ID Name
 IPR001496  SOCS box domain
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR036036  SOCS box-like domain superfamily
 IPR037340  SSB2, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Spsb2tm1Nch/Spsb2+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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