ENSMUSG00000035824


Mus musculus

Features
Gene ID: ENSMUSG00000035824
  
Biological name :Tk2
  
Synonyms : thymidine kinase 2, mitochondrial / Tk2
  
Possible biological names infered from orthology : O00142
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 104226685
Gene end: 104248558
  
Corresponding Affymetrix probe sets: 10581036 (MoGene1.0st)   1426100_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148384
Ensembl peptide - ENSMUSP00000148733
Ensembl peptide - ENSMUSP00000148642
Ensembl peptide - ENSMUSP00000053616
Ensembl peptide - ENSMUSP00000148375
NCBI entrez gene - 57813     See in Manteia.
MGI - MGI:1913266
RefSeq - XM_017312925
RefSeq - XM_006531235
RefSeq - XM_011248461
RefSeq - XM_006531234
RefSeq - XM_006531233
RefSeq - NM_021028
RefSeq Peptide - NP_066356
swissprot - Q8BN51
swissprot - A0A1D5RLI6
swissprot - A0A1D5RLH9
swissprot - A0A1D5RMD6
Ensembl - ENSMUSG00000035824
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tk2ENSDARG00000046127Danio rerio
 TK2ENSGALG00000034216Gallus gallus
 TK2ENSG00000166548Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dck / P43346 / Deoxycytidine kinase / P27707*ENSMUSG0000002936630
Dguok / Q9QX60 / Deoxyguanosine kinase, mitochondrial / Q16854* / deoxyguanosine kinase*ENSMUSG0000001455429


Protein motifs (from Interpro)
Interpro ID Name
 IPR002624  Deoxynucleoside kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031314  Deoxynucleoside kinase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0009157 deoxyribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046092 deoxycytidine metabolic process IEA
 biological_processGO:0046104 thymidine metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0004137 deoxycytidine kinase activity IEA
 molecular_functionGO:0004797 thymidine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019206 nucleoside kinase activity IEA


Pathways (from Reactome)
Pathway description
Pyrimidine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tk2tm1Mihi/Tk2tm1Mihi
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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