ENSMUSG00000029366


Mus musculus

Features
Gene ID: ENSMUSG00000029366
  
Biological name :Dck
  
Synonyms : Dck / Deoxycytidine kinase / P43346
  
Possible biological names infered from orthology : P27707
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 88764996
Gene end: 88783281
  
Corresponding Affymetrix probe sets: 10523012 (MoGene1.0st)   1428838_a_at (Mouse Genome 430 2.0 Array)   1439012_a_at (Mouse Genome 430 2.0 Array)   1449176_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031311
NCBI entrez gene - 13178     See in Manteia.
MGI - MGI:102726
RefSeq - NM_007832
RefSeq Peptide - NP_031858
swissprot - P43346
swissprot - Q545E8
Ensembl - ENSMUSG00000029366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dckENSDARG00000044807Danio rerio
 DCKENSGALG00000028501Gallus gallus
 DCKENSG00000156136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dguok / Q9QX60 / Deoxyguanosine kinase, mitochondrial / Q16854* / deoxyguanosine kinase*ENSMUSG0000001455445
Tk2 / thymidine kinase 2, mitochondrial / O00142*ENSMUSG0000003582431


Protein motifs (from Interpro)
Interpro ID Name
 IPR002624  Deoxynucleoside kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031314  Deoxynucleoside kinase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006220 pyrimidine nucleotide metabolic process IEA
 biological_processGO:0009157 deoxyribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004137 deoxycytidine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019206 nucleoside kinase activity ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Pyrimidine salvage
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Adamts20m7Btlr/Adamts20m7Btlr
Genetic Background: C57BL/6J-Adamts20m7Btlr

Allelic Composition: Dckm1Btlr/Dck+
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20m7Btlr/Adamts20m7Btlr
Genetic Background: C57BL/6J-Adamts20m7Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm3(cre)Chg/Shhtm3(cre)Chg
Genetic Background: Not Specified

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20m7Btlr/Adamts20m7Btlr
Genetic Background: C57BL/6J-Adamts20m7Btlr

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

Allelic Composition: Dckm1Btlr/Dckm1Btlr
Genetic Background: C57BL/6J-Dckm1Btlr

Allelic Composition: Dckm1Btlr/Dck+
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Dckm1Btlr/Dckm1Btlr
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

Allelic Composition: Dckm1Btlr/Dckm1Btlr
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dckm1Btlr/Dckm1Btlr
Genetic Background: C57BL/6J-Dckm1Btlr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0008463 abnormal peripheral lymph node morphology "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Dckm1Btlr/Dckm1Btlr
Genetic Background: C57BL/6J-Dckm1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029366 Dck / P43346 / Deoxycytidine kinase / P27707*  / complex






 

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