ENSMUSG00000036181


Mus musculus

Features
Gene ID: ENSMUSG00000036181
  
Biological name :Hist1h1c
  
Synonyms : Hist1h1c / histone cluster 1, H1c / P15864
  
Possible biological names infered from orthology : histone cluster 1 H1 family member c / P16403
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 23738808
Gene end: 23740367
  
Corresponding Affymetrix probe sets: 10404059 (MoGene1.0st)   1416101_a_at (Mouse Genome 430 2.0 Array)   1436994_a_at (Mouse Genome 430 2.0 Array)   1438204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045816
NCBI entrez gene - 50708     See in Manteia.
MGI - MGI:1931526
RefSeq - NM_015786
RefSeq Peptide - NP_056601
swissprot - P15864
swissprot - Q5SZA3
Ensembl - ENSMUSG00000036181
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 histh1lENSDARG00000035519Danio rerio
 si:ch1073-153i20.4ENSDARG00000105350Danio rerio
 si:ch1073-159d7.7ENSDARG00000074012Danio rerio
 si:ch211-103n10.5ENSDARG00000077504Danio rerio
 si:ch211-113a14.18ENSDARG00000051735Danio rerio
 si:ch211-113a14.24ENSDARG00000051718Danio rerio
 si:ch73-368j24.11ENSDARG00000105430Danio rerio
 si:ch73-368j24.12ENSDARG00000105502Danio rerio
 si:ch73-36p18.1ENSDARG00000115766Danio rerio
 si:dkey-108k21.10ENSDARG00000075508Danio rerio
 si:dkey-108k21.14ENSDARG00000110841Danio rerio
 si:dkey-108k21.21ENSDARG00000091905Danio rerio
 si:dkey-23a13.17ENSDARG00000105328Danio rerio
 si:dkey-23a13.9ENSDARG00000105431Danio rerio
 si:dkey-261m9.12ENSDARG00000032637Danio rerio
 zgc:110216ENSDARG00000077456Danio rerio
 zgc:110425ENSDARG00000058479Danio rerio
 zgc:153405ENSDARG00000096992Danio rerio
 zgc:163061ENSDARG00000075538Danio rerio
 zgc:163061ENSDARG00000076766Danio rerio
 ENSGALG00000011747Gallus gallus
 HIST1H111RENSGALG00000011783Gallus gallus
 P08284ENSGALG00000031874Gallus gallus
 P08285ENSGALG00000037167Gallus gallus
 P08286ENSGALG00000031159Gallus gallus
 P16403ENSG00000187837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P43277 / Hist1h1d / Histone H1.3 / P16402* / histone cluster 1 H1 family member d*ENSMUSG0000005256585
P43274 / Hist1h1e / Histone H1.4 / P10412* / histone cluster 1 H1 family member e*ENSMUSG0000005162784
P43276 / Hist1h1b / Histone H1.5 / P16401* / histone cluster 1 H1 family member b*ENSMUSG0000005877379
Gm6970 / P16401* / HIST1H1B* / histone cluster 1 H1 family member b*ENSMUSG0000009123066
P43275 / Hist1h1a / Histone H1.1 / Q02539* / histone cluster 1 H1 family member a*ENSMUSG0000004953966
Hist1h1t / histone cluster 1 H1 family member t / P22492*ENSMUSG0000003621150


Protein motifs (from Interpro)
Interpro ID Name
 IPR005818  Linker histone H1/H5, domain H15
 IPR005819  Histone H5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0016584 nucleosome positioning IMP
 biological_processGO:0080182 histone H3-K4 trimethylation IGI
 biological_processGO:0098532 histone H3-K27 trimethylation IGI
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm1Ais/Hist1h1ctm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0004587 decreased cellular sensitivity to X-ray irradiation "decreased incidence of cell death following exposure to high levels of X-ray irradiation" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm2Ais/Hist1h1d+,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0012156 rostral-caudal axis duplication "partial or complete duplication of rostral-caudal axis structures" [MGI:anna]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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