ENSMUSG00000036270


Mus musculus

Features
Gene ID: ENSMUSG00000036270
  
Biological name :Edc4
  
Synonyms : Edc4 / enhancer of mRNA decapping 4
  
Possible biological names infered from orthology : Q6P2E9
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105880881
Gene end: 105894908
  
Corresponding Affymetrix probe sets: 10574903 (MoGene1.0st)   10574934 (MoGene1.0st)   1426874_at (Mouse Genome 430 2.0 Array)   1456819_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039134
Ensembl peptide - ENSMUSP00000114209
Ensembl peptide - ENSMUSP00000114285
Ensembl peptide - ENSMUSP00000118162
Ensembl peptide - ENSMUSP00000113854
NCBI entrez gene - 234699     See in Manteia.
MGI - MGI:2446249
RefSeq - XM_017312743
RefSeq - NM_001301100
RefSeq - NM_181594
RefSeq - XM_006530901
RefSeq - XM_006530902
RefSeq - XM_006530904
RefSeq - XM_006530905
RefSeq Peptide - NP_853625
RefSeq Peptide - NP_001288029
swissprot - F6ZJ27
swissprot - D6RE33
swissprot - A0A0R4J1Q0
swissprot - G5E896
swissprot - F6V5I7
Ensembl - ENSMUSG00000036270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edc4ENSDARG00000062266Danio rerio
 EDC4ENSGALG00000040875Gallus gallus
 EDC4ENSG00000038358Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR032401  Enhancer of mRNA-decapping protein 4, WD40 repeat region
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 5 to 3 exoribonuclease


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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