ENSMUSG00000036427


Mus musculus

Features
Gene ID: ENSMUSG00000036427
  
Biological name :Gpi1
  
Synonyms : glucose phosphate isomerase 1 / Gpi1 / P06745
  
Possible biological names infered from orthology : glucose-6-phosphate isomerase / GPI / P06744
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 34201330
Gene end: 34230336
  
Corresponding Affymetrix probe sets: 10562360 (MoGene1.0st)   10570000 (MoGene1.0st)   1420997_a_at (Mouse Genome 430 2.0 Array)   1434814_x_at (Mouse Genome 430 2.0 Array)   1450081_x_at (Mouse Genome 430 2.0 Array)   1456909_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049355
Ensembl peptide - ENSMUSP00000146273
Ensembl peptide - ENSMUSP00000146209
Ensembl peptide - ENSMUSP00000145929
Ensembl peptide - ENSMUSP00000145891
Ensembl peptide - ENSMUSP00000145839
NCBI entrez gene - 14751     See in Manteia.
MGI - MGI:95797
RefSeq - NM_008155
RefSeq Peptide - NP_032181
swissprot - A0A0U1RP97
swissprot - A0A0U1RP58
swissprot - A0A0U1RQ72
swissprot - P06745
swissprot - A0A0U1RQ18
swissprot - A0A0U1RPC9
Ensembl - ENSMUSG00000036427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpiaENSDARG00000012987Danio rerio
 gpibENSDARG00000103826Danio rerio
 GPIENSGALG00000004956Gallus gallus
 GPIENSG00000105220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001672  Phosphoglucose isomerase (PGI)
 IPR018189  Phosphoglucose isomerase, conserved site
 IPR023096  Phosphoglucose isomerase, C-terminal
 IPR035476  Phosphoglucose isomerase, SIS domain 1
 IPR035482  Phosphoglucose isomerase, SIS domain 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019242 methylglyoxal biosynthetic process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0046185 aldehyde catabolic process IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISO
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 biological_processGO:0061620 glycolytic process through glucose-6-phosphate IC
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0060170 ciliary membrane IDA
 molecular_functionGO:0004347 glucose-6-phosphate isomerase activity IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0016866 intramolecular transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0048029 monosaccharide binding IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes
Neutrophil degranulation
Glycolysis
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-M5H/Gpi1b-M5H
Genetic Background: involves: C3H/HeH

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Brca2tm1Arge/Brca2tm2Arge
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gpi1b-m2Neu/Gpi1b-m2Neu
Genetic Background: C3.Cg-Gpi1b-m2Neu

Allelic Composition: Gpi1b-m1H/Gpi1b-m1H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Gpi1b-m2H/Gpi1b-m2H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036427 Gpi1 / P06745 / glucose phosphate isomerase 1 / GPI* / P06744* / glucose-6-phosphate isomerase*  / complex






 

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