Manteia - Molecule gene

ENSMUSG00000036792

Mus musculus

Features

Gene ID:	ENSMUSG00000036792

Biological name :	Mbd5

Synonyms :	B1AYB6 / Mbd5 / Methyl-CpG-binding domain protein 5

Possible biological names infered from orthology :	Q9P267

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	C1.1
Gene start:	48949508
Gene end:	49325405

Corresponding Affymetrix probe sets:	10471967 (MoGene1.0st) 1441987_at (Mouse Genome 430 2.0 Array) 1453507_at (Mouse Genome 430 2.0 Array) 1456423_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000108365 Ensembl peptide - ENSMUSP00000143413 Ensembl peptide - ENSMUSP00000143148 Ensembl peptide - ENSMUSP00000143060 Ensembl peptide - ENSMUSP00000142821 Ensembl peptide - ENSMUSP00000137021 Ensembl peptide - ENSMUSP00000119317 Ensembl peptide - ENSMUSP00000108374 Ensembl peptide - ENSMUSP00000036847 NCBI entrez gene - 109241 See in Manteia. MGI - MGI:2138934 RefSeq - XM_017314916 RefSeq - XM_017314915 RefSeq - XM_017314914 RefSeq - XM_017314912 RefSeq - XM_017314911 RefSeq - XM_017314910 RefSeq - XM_017314909 RefSeq - NM_001290656 RefSeq - XM_006497604 RefSeq - NM_029924 RefSeq Peptide - NP_001277585 RefSeq Peptide - NP_084200 swissprot - Q3TTF1 swissprot - B1AYB7 swissprot - F6Q8U1 swissprot - A0A0G2JEL9 swissprot - A0A0G2JF81 swissprot - A0A0G2JFF3 swissprot - A0A0G2JG39 swissprot - B1AYB5 swissprot - B1AYB6 Ensembl - ENSMUSG00000036792

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mbd5	ENSDARG00000059581	Danio rerio
MBD5	ENSGALG00000012449	Gallus gallus
MBD5	ENSG00000204406	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mbd6 / Q3TY92 / Mus musculus methyl-CpG binding domain protein 6 (Mbd6), transcript variant 2, mRNA. / Q96DN6* / methyl-CpG binding domain protein 6*	ENSMUSG00000025409	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000313	PWWP domain
IPR001739	Methyl-CpG DNA binding
IPR016177	DNA-binding domain superfamily
IPR037385	Methyl-CpG-binding domain protein 5/6

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0040014	regulation of multicellular organism growth	IMP
biological_process	GO:0042593	glucose homeostasis	IMP
biological_process	GO:0050795	regulation of behavior	IEA
biological_process	GO:0060399	positive regulation of growth hormone receptor signaling pathway	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005694	chromosome	IEA
cellular_component	GO:0010369	chromocenter	IEA
cellular_component	GO:0030496	midbody	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IEA

Pathways (from Reactome)

Pathway description

UCH proteinases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000102	abnormal nasal bone morphology	"malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Mbd5^tm1.1Gxu/Mbd5^tm1.1Gxu,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0001360	abnormal social investigation	"altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1Hay/Htt^tm1Hay,Tg(HTT97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay Genetic Background:* FVB.Cg-Htt^tm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0001441	increased grooming behavior	"increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Mbd5^tm1.1Gxu/Mbd5^tm1.1Gxu,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
MP:0002063	abnormal learning/memory/conditioning	"altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1Hay/Htt^tm1Hay,Tg(HTT97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay Genetic Background:* FVB.Cg-Htt^tm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1Hay/Htt^tm1Hay,Tg(HTT97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay Genetic Background:* FVB.Cg-Htt^tm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Marveld2^{tm1b(EUCOMM)Wtsi}/Marveld2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Marveld2^{tm1b(EUCOMM)Wtsi}/H
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Marveld2^{tm1b(EUCOMM)Wtsi}/Marveld2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Marveld2^{tm1b(EUCOMM)Wtsi}/H
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0003461	abnormal response to novel object	"altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0003769	abnormal lip morphology	"anomalous structure or development of the fleshy margins of the mouth" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Marveld2^{tm1b(EUCOMM)Wtsi}/Marveld2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Marveld2^{tm1b(EUCOMM)Wtsi}/H
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Mbd5^tm1.1Gxu/Mbd5^tm1.1Gxu,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Marveld2^{tm1b(EUCOMM)Wtsi}/Marveld2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Marveld2^{tm1b(EUCOMM)Wtsi}/H
MP:0005120	decreased circulating growth hormone level	"less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mbd5^tm1.1Gxu/Mbd5^tm1.1Gxu,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
MP:0005136	decreased growth hormone level	"less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0005361	small pituitary gland	"reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0008853	decreased abdominal adipose tissue amount	"reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺ Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}
MP:0010507	shortened RR interval	"reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Marveld2^{tm1b(EUCOMM)Wtsi}/Marveld2^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Marveld2^{tm1b(EUCOMM)Wtsi}/H
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hormad2^tm1Kura/Hormad2^tm1Kura,Spo11^tm1Mjn/Spo11^tm1Mjn Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Mbd5^tm1.1Gxu/Mbd5^tm1.1Gxu,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Htt^tm1Hay/Htt^tm1Hay,Tg(HTT97Q)IXwy/0,Tg(YAC18)18Hay/Tg(YAC18)18Hay Genetic Background:* FVB.Cg-Htt^tm1Hay Tg(HTT*97Q)IXwy Tg(YAC18)18Hay

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr