ENSMUSG00000036932


Mus musculus

Features
Gene ID: ENSMUSG00000036932
  
Biological name :Aifm1
  
Synonyms : Aifm1 / Apoptosis-inducing factor 1, mitochondrial / Q9Z0X1
  
Possible biological names infered from orthology : apoptosis inducing factor mitochondria associated 1 / O95831
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A5
Gene start: 48474944
Gene end: 48513563
  
Corresponding Affymetrix probe sets: 10604405 (MoGene1.0st)   1418127_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041104
Ensembl peptide - ENSMUSP00000110595
NCBI entrez gene - 26926     See in Manteia.
MGI - MGI:1349419
RefSeq - NM_001290364
RefSeq - NM_012019
RefSeq Peptide - NP_001277293
RefSeq Peptide - NP_036149
swissprot - Q9Z0X1
swissprot - B1AU25
Ensembl - ENSMUSG00000036932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aifm1ENSDARG00000058088Danio rerio
 AIFM1ENSGALG00000004003Gallus gallus
 AIFM1ENSG00000156709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aifm3 / Q3TY86 / Apoptosis-inducing factor 3 / Q96NN9* / apoptosis inducing factor, mitochondria associated 3*ENSMUSG0000002276319


Protein motifs (from Interpro)
Interpro ID Name
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR029324  Mitochondrial apoptosis-inducing factor, C-terminal domain
 IPR032773  Protein MGARP, N-terminal
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress TAS
 biological_processGO:0008637 apoptotic mitochondrial changes TAS
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010942 positive regulation of cell death IMP
 biological_processGO:0022904 respiratory electron transport chain IEA
 biological_processGO:0030182 neuron differentiation ISO
 biological_processGO:0032981 mitochondrial respiratory chain complex I assembly ISO
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation IEA
 biological_processGO:1902065 response to L-glutamate IEA
 biological_processGO:1902510 regulation of apoptotic DNA fragmentation IGI
 biological_processGO:1904045 cellular response to aldosterone IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004174 electron-transferring-flavoprotein dehydrogenase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016174 NAD(P)H oxidase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016651 oxidoreductase activity, acting on NAD(P)H IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0071949 FAD binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1Hq/Aifm1+
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Aifm1Hq/Aifm1Hq
Genetic Background: involves: CF-1

Allelic Composition: Aifm1Hq/Y
Genetic Background: involves: CF-1

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0000950 pharmacologically induced seizures "seizure activity that is brought about by treatment with pharmacological agents" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1Hq/Aifm1Hq
Genetic Background: involves: CF-1

Allelic Composition: Aifm1Hq/Y
Genetic Background: involves: CF-1

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Aifm1Hq/Aifm1Hq,Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger4tm1.2Matb/Ptger4tm1.2Matb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cplx3tm1Rmnd/Cplx3tm1Rmnd,Cplx4tm1Bros/Cplx4tm1Bros
Genetic Background: involves: C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr,Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006039 decreased mitochondrial proliferation "less than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008103 amacrine cell degeneration "a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0008775 abnormal heart ventricular pressure "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Aifm1tm2.1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

Allelic Composition: Aifm1tm2.1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aifm1tm2Pngr/Aifm1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aifm1tm2Pngr/Y,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011593 increased catalase activity "greater ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0011594 decreased catalase activity "reduced ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
Show

Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011628 increased mitochondria number "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Aifm1tm2.1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012660 increased superoxide dismutase level 
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Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Aifm1Hq/Y
Genetic Background: B6CBACa Aw-J/A-Aifm1Hq/J

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Aifm1tm2Pngr/Y,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Aifm1tm2.1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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