ENSMUSG00000037020


Mus musculus

Features
Gene ID: ENSMUSG00000037020
  
Biological name :Wdr62
  
Synonyms : Wdr62 / WD repeat domain 62
  
Possible biological names infered from orthology : O43379
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30240138
Gene end: 30280419
  
Corresponding Affymetrix probe sets: 10561868 (MoGene1.0st)   1424849_at (Mouse Genome 430 2.0 Array)   1431376_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116772
Ensembl peptide - ENSMUSP00000103825
Ensembl peptide - ENSMUSP00000116139
NCBI entrez gene - 233064     See in Manteia.
MGI - MGI:1923696
RefSeq - XM_011250545
RefSeq - XM_011250541
RefSeq - XM_011250542
RefSeq - XM_011250543
RefSeq - XM_011250544
RefSeq - NM_146186
RefSeq - XM_006539875
RefSeq - XM_006539877
RefSeq - XM_006539879
RefSeq - XM_006539880
RefSeq - XM_006539881
RefSeq - XM_011250540
RefSeq Peptide - NP_666298
swissprot - F6R9F0
swissprot - E9QK36
swissprot - E9PUI7
Ensembl - ENSMUSG00000037020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr62ENSDARG00000060312Danio rerio
 WDR62ENSG00000075702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapkbp1 / Mus musculus mitogen-activated protein kinase binding protein 1 (Mapkbp1), transcript variant 1, mRNA. / O60336* / mitogen-activated protein kinase binding protein 1*ENSMUSG0000003390237


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022008 neurogenesis IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0006123 tricuspid valve atresia "congenital closure of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0011665 d-loop transposition of the great arteries "complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Dnah11b2b1289Clo/Dnah11b2b1289Clo
Genetic Background: C57BL/6J-Dnah11b2b1289Clo

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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