ENSMUSG00000037202


Mus musculus

Features
Gene ID: ENSMUSG00000037202
  
Biological name :Prf1
  
Synonyms : P10820 / perforin 1 (pore forming protein) / Prf1
  
Possible biological names infered from orthology : P14222 / perforin 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 61297833
Gene end: 61304680
  
Corresponding Affymetrix probe sets: 10363475 (MoGene1.0st)   1451862_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151354
Ensembl peptide - ENSMUSP00000041483
NCBI entrez gene - 18646     See in Manteia.
MGI - MGI:97551
RefSeq - NM_011073
RefSeq - XM_006513370
RefSeq Peptide - NP_035203
swissprot - A2RSY7
swissprot - P10820
Ensembl - ENSMUSG00000037202
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prf1.1ENSDARG00000030394Danio rerio
 prf1.2ENSDARG00000021444Danio rerio
 prf1.3ENSDARG00000001572Danio rerio
 prf1.5ENSDARG00000037598Danio rerio
 prf1.6ENSDARG00000024522Danio rerio
 prf1.7ENSDARG00000110781Danio rerio
 prf1.7ENSDARG00000109428Danio rerio
 prf1.9ENSDARG00000060662Danio rerio
 ENSGALG00000045916Gallus gallus
 PRF1ENSG00000180644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR035892  C2 domain superfamily
 IPR037300  Perforin-1, C2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation ISO
 biological_processGO:0002357 defense response to tumor cell IMP
 biological_processGO:0002418 immune response to tumor cell IMP
 biological_processGO:0019835 cytolysis IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0051712 positive regulation of killing of cells of other organism ISO
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031904 endosome lumen IEA
 cellular_componentGO:0044194 cytolytic granule ISO
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0022829 wide pore channel activity IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,X/Yaa
Genetic Background: BXSB.B6-Prf1tm1Sdz/Dcr

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Gt(ROSA)26Sortm39.1(CAG-hop/EYFP)Hze/Gt(ROSA)26Sor+,Shox2tm1.1(cre)Oki/Shox2+
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: A.B6-Prf1tm1Sdz

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.B6-Prf1tm1Sdz

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S7-Ldlrtm1Her Ifngtm1Ts

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S7-Ldlrtm1Her Ifngtm1Ts

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,X/Yaa
Genetic Background: BXSB.B6-Prf1tm1Sdz/Dcr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igkc+,Igk-Jtm1(CD4*)Mss/Igk-J+
Genetic Background: involves: 129S4/SvJae

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: B6.MRL-Faslpr/J

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Tg(Tcra2B4)1Mmd/?,Tg(Tcrb2B4)1Mmd/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

Allelic Composition: Prf1m1Btlr/Prf1m1Btlr
Genetic Background: C57BL/6J-Prf1m1Btlr

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: involves: 129S2/SvPas

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.B6-Prf1tm1Sdz

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc2tm2.1Djk/Tsc2tm2.1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003865 lymph node inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: NOD.B6-Prf1tm1Sdz

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apbb1tm1Her/Apbb1tm1Her,Apbb2tm1Her/Apbb2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk,Tg(INS-Il10)#Sar/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.B6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: NOD.B6-Prf1tm1Sdz

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Prf1tm1Tsc/Prf1+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: A.B6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: A.B6-Prf1tm1Sdz

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Prf1tm1Tsc/Prf1+
Genetic Background: involves: 129S2/SvPas

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ

 MP:0005580 periinsulitis "early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [J:11442, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Prf1tm1Sdz/Prf1+
Genetic Background: NOD.B6-Prf1tm1Sdz

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

Allelic Composition: Bmgr2C57BL/6J/?,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Bmgr3129S6/SvEvTac/Bmgr3129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Bmgr4C57BL/6J/?,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Bmgr4C57BL/6J/?,Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc2tm2.1Djk/Tsc2tm2.1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ins2Akita/Ins2+,Prf1tm1Sdz/Prf1tm1Sdz,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Ins2Akita Prf1tm1Sdz

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/Sz

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

 MP:0008791 decreased NK cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: NOD.B6-Prf1tm1Sdz

 MP:0009022 abnormal brain meninges morphology "any structural anomaly in any of the membranes covering the brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: 129X1.129S2-Prf1tm1Tsc

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

Allelic Composition: Prf1m1Btlr/Prf1m1Btlr
Genetic Background: C57BL/6J-Prf1m1Btlr

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.B6-Prf1tm1Sdz

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Tsc/Prf1tm1Tsc
Genetic Background: 129X1.129S2-Prf1tm1Tsc

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nr3c1Gt(ESKN92)Hgs/Nr3c1+
Genetic Background: B6.Cg-Nr3c1Gt(ESKN92)Hgs

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz/J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C57BL/6-Prf1tm1Sdz

Allelic Composition: Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.B6-Prf1tm1Sdz

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr