ENSMUSG00000037570


Mus musculus

Features
Gene ID: ENSMUSG00000037570
  
Biological name :Mcrs1
  
Synonyms : Mcrs1 / microspherule protein 1 / Q99L90
  
Possible biological names infered from orthology : Q96EZ8
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 99242817
Gene end: 99251961
  
Corresponding Affymetrix probe sets: 10432411 (MoGene1.0st)   1416535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154847
Ensembl peptide - ENSMUSP00000043901
Ensembl peptide - ENSMUSP00000131407
Ensembl peptide - ENSMUSP00000155583
Ensembl peptide - ENSMUSP00000155008
Ensembl peptide - ENSMUSP00000155541
NCBI entrez gene - 51812     See in Manteia.
MGI - MGI:1858420
RefSeq - NM_001164156
RefSeq - NM_016766
RefSeq Peptide - NP_001157628
RefSeq Peptide - NP_058046
swissprot - Q3TJY1
swissprot - Q99L90
Ensembl - ENSMUSG00000037570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcrs1ENSDARG00000020840Danio rerio
 MCRS1ENSG00000187778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR008984  SMAD/FHA domain superfamily
 IPR025999  Microspherule protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0051974 negative regulation of telomerase activity ISO
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening ISO
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008266 poly(U) RNA binding IEA
 molecular_functionGO:0010521 telomerase inhibitor activity ISO
 molecular_functionGO:0034046 poly(G) binding IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr