ENSMUSG00000037580


Mus musculus

Features
Gene ID: ENSMUSG00000037580
  
Biological name :Gch1
  
Synonyms : Gch1 / GTP cyclohydrolase 1 / Q05915
  
Possible biological names infered from orthology : P30793
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 47153895
Gene end: 47189413
  
Corresponding Affymetrix probe sets: 10419288 (MoGene1.0st)   1420499_at (Mouse Genome 430 2.0 Array)   1429692_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087405
NCBI entrez gene - 14528     See in Manteia.
MGI - MGI:95675
RefSeq - NM_008102
RefSeq Peptide - NP_032128
swissprot - Q05915
swissprot - Q3U7P6
Ensembl - ENSMUSG00000037580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU464134.2ENSDARG00000113158Danio rerio
 gch1ENSDARG00000070453Danio rerio
 GCH1ENSGALG00000012200Gallus gallus
 GCH1ENSG00000131979Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001474  GTP cyclohydrolase I
 IPR018234  GTP cyclohydrolase I, conserved site
 IPR020602  GTP cyclohydrolase I domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010460 positive regulation of heart rate IMP
 biological_processGO:0014916 regulation of lung blood pressure IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035998 7,8-dihydroneopterin 3"-triphosphate biosynthetic process IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042559 pteridine-containing compound biosynthetic process IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0050884 neuromuscular process controlling posture IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051066 dihydrobiopterin metabolic process IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide TAS
 biological_processGO:1905627 regulation of serotonin biosynthetic process NAS
 biological_processGO:2000121 regulation of removal of superoxide radicals IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0003934 GTP cyclohydrolase I activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005525 GTP binding IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050662 coenzyme binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046814 Gchfr / P99025 / GTP cyclohydrolase 1 feedback regulatory protein / P30047* / GTP cyclohydrolase I feedback regulator*  / complex / reaction
 ENSMUSG00000037580 Gch1 / Q05915 / GTP cyclohydrolase 1 / P30793*  / complex






 

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