ENSMUSG00000037622


Mus musculus

Features
Gene ID: ENSMUSG00000037622
  
Biological name :Wdtc1
  
Synonyms : Q80ZK9 / WD and tetratricopeptide repeats 1 / Wdtc1
  
Possible biological names infered from orthology : Q8N5D0
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 133292459
Gene end: 133353481
  
Corresponding Affymetrix probe sets: 10517036 (MoGene1.0st)   1434560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040647
Ensembl peptide - ENSMUSP00000101526
NCBI entrez gene - 230796     See in Manteia.
MGI - MGI:2685541
RefSeq - XM_006538746
RefSeq - NM_199306
RefSeq - XM_006538743
RefSeq - XM_006538744
RefSeq - XM_006538745
RefSeq Peptide - NP_955010
swissprot - Q80ZK9
swissprot - A2AE98
Ensembl - ENSMUSG00000037622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdtc1ENSDARG00000059760Danio rerio
 WDTC1ENSGALG00000000943Gallus gallus
 WDTC1ENSG00000142784Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dcaf6 / Q9DC22 / DDB1- and CUL4-associated factor 6 / Q58WW2*ENSMUSG0000002657125
Dcaf8 / Q8N7N5 / DDB1- and CUL4-associated factor 8 / Q5TAQ9* / AL139011.2*ENSMUSG0000002655421
Pet2 / A6NGE4* / P0C7V8* / DCAF8L2* / DCAF8L1* / DDB1 and CUL4 associated factor 8 like 2* / DDB1 and CUL4 associated factor 8 like 1*ENSMUSG0000003539518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IMP
 biological_processGO:0055082 cellular chemical homeostasis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Faslpr/Faslpr,Selplgtm1Fur/Selplgtm1Fur
Genetic Background: MRL.Cg-Selplgtm1Fur Faslpr

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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