ENSMUSG00000037798


Mus musculus

Features
Gene ID: ENSMUSG00000037798
  
Biological name :Mat1a
  
Synonyms : Mat1a / Q91X83 / S-adenosylmethionine synthase isoform type-1
  
Possible biological names infered from orthology : methionine adenosyltransferase 1A / Q00266
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 41105035
Gene end: 41124412
  
Corresponding Affymetrix probe sets: 10414192 (MoGene1.0st)   1423147_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153488
Ensembl peptide - ENSMUSP00000044288
Ensembl peptide - ENSMUSP00000152905
NCBI entrez gene - 11720     See in Manteia.
MGI - MGI:88017
RefSeq - NM_133653
RefSeq - XM_006518450
RefSeq Peptide - NP_598414
swissprot - A0A286YCQ9
swissprot - Q91X83
Ensembl - ENSMUSG00000037798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mat1aENSDARG00000039605Danio rerio
 MAT1AENSGALG00000002479Gallus gallus
 MAT1AENSG00000151224Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mat2a / Q3THS6 / methionine adenosyltransferase II, alpha / P31153* / methionine adenosyltransferase 2A*ENSMUSG0000005390784


Protein motifs (from Interpro)
Interpro ID Name
 IPR002133  S-adenosylmethionine synthetase
 IPR022628  S-adenosylmethionine synthetase, N-terminal
 IPR022629  S-adenosylmethionine synthetase, central domain
 IPR022630  S-adenosylmethionine synthetase, C-terminal
 IPR022631  S-adenosylmethionine synthetase, conserved site
 IPR022636  S-adenosylmethionine synthetase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006556 S-adenosylmethionine biosynthetic process ISO
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0009087 methionine catabolic process ISO
 biological_processGO:0051289 protein homotetramerization ISO
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004478 methionine adenosyltransferase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism
Metabolism of ingested SeMet, Sec, MeSec into H2Se


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Tbx20tm1.1Sev/Tbx20tm1.1Sev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037798 Mat1a / Q91X83 / S-adenosylmethionine synthase isoform type-1 / Q00266* / methionine adenosyltransferase 1A*  / complex






 

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