ENSMUSG00000053907


Mus musculus

Features
Gene ID: ENSMUSG00000053907
  
Biological name :Mat2a
  
Synonyms : Mat2a / methionine adenosyltransferase II, alpha / Q3THS6
  
Possible biological names infered from orthology : methionine adenosyltransferase 2A / P31153
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 72432799
Gene end: 72439558
  
Corresponding Affymetrix probe sets: 10545417 (MoGene1.0st)   1423667_at (Mouse Genome 430 2.0 Array)   1433576_at (Mouse Genome 430 2.0 Array)   1438386_x_at (Mouse Genome 430 2.0 Array)   1438630_x_at (Mouse Genome 430 2.0 Array)   1438976_x_at (Mouse Genome 430 2.0 Array)   1439386_x_at (Mouse Genome 430 2.0 Array)   1456702_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087118
Ensembl peptide - ENSMUSP00000146319
Ensembl peptide - ENSMUSP00000146301
Ensembl peptide - ENSMUSP00000145983
Ensembl peptide - ENSMUSP00000145696
Ensembl peptide - ENSMUSP00000145603
NCBI entrez gene - 232087     See in Manteia.
MGI - MGI:2443731
RefSeq - NM_145569
RefSeq Peptide - NP_663544
swissprot - A0A0U1RNT6
swissprot - A0A0U1RNK6
swissprot - Q3THS6
swissprot - A0A0U1RQB0
swissprot - Q99J57
swissprot - A0A0U1RQ95
swissprot - A0A0U1RPH4
Ensembl - ENSMUSG00000053907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mat2aaENSDARG00000040334Danio rerio
 mat2abENSDARG00000037121Danio rerio
 MAT2AENSG00000168906Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mat1a / Q91X83 / S-adenosylmethionine synthase isoform type-1 / Q00266* / methionine adenosyltransferase 1A*ENSMUSG0000003779884


Protein motifs (from Interpro)
Interpro ID Name
 IPR002133  S-adenosylmethionine synthetase
 IPR022628  S-adenosylmethionine synthetase, N-terminal
 IPR022629  S-adenosylmethionine synthetase, central domain
 IPR022630  S-adenosylmethionine synthetase, C-terminal
 IPR022631  S-adenosylmethionine synthetase, conserved site
 IPR022636  S-adenosylmethionine synthetase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006556 S-adenosylmethionine biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0048269 methionine adenosyltransferase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004478 methionine adenosyltransferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005387 immune system phenotype 
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042032 Mat2b / Q99LB6 / Methionine adenosyltransferase 2 subunit beta / Q9NZL9* / methionine adenosyltransferase 2B*  / complex






 

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contact: otassy@igbmc.fr