ENSDARG00000040334


Danio rerio

Features
Gene ID: ENSDARG00000040334
  
Biological name :mat2aa
  
Synonyms : mat2aa / methionine adenosyltransferase II, alpha a
  
Possible biological names infered from orthology : MAT2A / methionine adenosyltransferase 2A / methionine adenosyltransferase II, alpha / P31153 / Q3THS6
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 7810455
Gene end: 7821686
  
Corresponding Affymetrix probe sets: Dr.2850.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105782
NCBI entrez gene - 323329     See in Manteia.
swissprot - F1QYU7
ZFIN ID - ZDB-GENE-030131-2049
Ensembl - ENSDARG00000040334
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAT2AENSG00000168906Homo sapiens
 Mat2aENSMUSG00000053907Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mat2ab / methionine adenosyltransferase II, alpha b / MAT2A* / Q3THS6* / P31153* / methionine adenosyltransferase 2A* / methionine adenosyltransferase II, alpha*ENSDARG0000003712185
mat1a / methionine adenosyltransferase I, alpha / Q00266* / Q91X83* / methionine adenosyltransferase 1A* / S-adenosylmethionine synthase isoform type-1 *ENSDARG0000003960581
mat2al / methionine adenosyltransferase II, alpha-likeENSDARG0000006366573


Protein motifs (from Interpro)
Interpro ID Name
 IPR002133  S-adenosylmethionine synthetase
 IPR022628  S-adenosylmethionine synthetase, N-terminal
 IPR022629  S-adenosylmethionine synthetase, central domain
 IPR022630  S-adenosylmethionine synthetase, C-terminal
 IPR022631  S-adenosylmethionine synthetase, conserved site
 IPR022636  S-adenosylmethionine synthetase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006556 S-adenosylmethionine biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0048269 methionine adenosyltransferase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004478 methionine adenosyltransferase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region aplastic , abnormal
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 ZFA:0005004 aortic arch aortic arch malformed , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased size , abnormal
cardiac muscle cell decreased amount , abnormal
cardiac muscle cell apoptotic process increased process quality , abnormal
cardiac muscle cell cell proliferation decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000012932 mat2b / methionine adenosyltransferase II, beta / Q9NZL9* / Q99LB6* / methionine adenosyltransferase 2B* / Methionine adenosyltransferase 2 subunit beta *  / complex






 

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