ENSMUSG00000038023


Mus musculus

Features
Gene ID: ENSMUSG00000038023
  
Biological name :Atp6v0a2
  
Synonyms : Atp6v0a2 / P15920 / V-type proton ATPase 116 kDa subunit a isoform 2
  
Possible biological names infered from orthology : ATPase H+ transporting V0 subunit a2 / Q9Y487
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 124628576
Gene end: 124724455
  
Corresponding Affymetrix probe sets: 10525804 (MoGene1.0st)   10525833 (MoGene1.0st)   1424513_at (Mouse Genome 430 2.0 Array)   1434791_at (Mouse Genome 430 2.0 Array)   1449870_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039737
Ensembl peptide - ENSMUSP00000143461
Ensembl peptide - ENSMUSP00000143284
NCBI entrez gene - 21871     See in Manteia.
MGI - MGI:104855
RefSeq - NM_011596
RefSeq Peptide - NP_035726
swissprot - A0A0G2JG81
swissprot - A0A0G2JFS2
swissprot - P15920
Ensembl - ENSMUSG00000038023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp6v0a2aENSDARG00000035538Danio rerio
 atp6v0a2bENSDARG00000035565Danio rerio
 ATP6V0A2ENSGALG00000003194Gallus gallus
 Q9Y487ENSG00000185344Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1G4 / Atp6v0a1 / ATPase, H+ transporting, lysosomal V0 subunit A1 / Q93050* / ATPase H+ transporting V0 subunit a1*ENSMUSG0000001930253
Tcirg1 / T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 / Q13488* / T cell immune regulator 1, ATPase H+ transporting V0 subunit a3*ENSMUSG0000000175052
Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*ENSMUSG0000003860051


Protein motifs (from Interpro)
Interpro ID Name
 IPR002490  V-type ATPase, V0 complex, 116kDa subunit family
 IPR026028  ATPase, V0 complex, subunit 116kDa, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0007035 vacuolar acidification IBA
 biological_processGO:0015986 ATP synthesis coupled proton transport IBA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0036295 cellular response to increased oxygen levels IEA
 biological_processGO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IBA
 cellular_componentGO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain IEA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016471 vacuolar proton-transporting V-type ATPase complex IBA
 cellular_componentGO:0033179 proton-transporting V-type ATPase, V0 domain IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IBA
 molecular_functionGO:0051117 ATPase binding IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019302 Q9Z1G4 / Atp6v0a1 / ATPase, H+ transporting, lysosomal V0 subunit A1 / Q93050* / ATPase H+ transporting V0 subunit a1*  / complex
 ENSMUSG00000038600 Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*  / complex
 ENSMUSG00000001750 Tcirg1 / T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 / Q13488* / T cell immune regulator 1, ATPase H+ transporting V0 subunit a3*  / complex






 

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