Manteia

ENSMUSG00000019302

Mus musculus

Features

Gene ID:	ENSMUSG00000019302

Biological name :	Atp6v0a1

Synonyms :	Atp6v0a1 / ATPase, H+ transporting, lysosomal V0 subunit A1 / Q9Z1G4

Possible biological names infered from orthology :	ATPase H+ transporting V0 subunit a1 / Q93050

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	101009452
Gene end:	101063719

Corresponding Affymetrix probe sets:	10381187 (MoGene1.0st) 1417632_at (Mouse Genome 430 2.0 Array) 1425227_a_at (Mouse Genome 430 2.0 Array) 1459924_at (Mouse Genome 430 2.0 Array) 1460650_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000090333 Ensembl peptide - ENSMUSP00000121247 Ensembl peptide - ENSMUSP00000131848 Ensembl peptide - ENSMUSP00000044838 Ensembl peptide - ENSMUSP00000099399 NCBI entrez gene - 11975 See in Manteia. MGI - MGI:103286 RefSeq - XM_006532055 RefSeq - NM_016920 RefSeq - XM_006532049 RefSeq - XM_006532050 RefSeq - XM_006532051 RefSeq - XM_006532052 RefSeq - XM_006532053 RefSeq - XM_006532054 RefSeq - NM_001243049 RefSeq - NM_001243050 RefSeq - NM_001243051 RefSeq Peptide - NP_058616 RefSeq Peptide - NP_001229978 RefSeq Peptide - NP_001229979 RefSeq Peptide - NP_001229980 swissprot - Q9Z1G4 swissprot - K3W4T3 swissprot - A2A599 Ensembl - ENSMUSG00000019302

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*	ENSMUSG00000038600	62
P15920 / Atp6v0a2 / V-type proton ATPase 116 kDa subunit a isoform 2 / Q9Y487* / ATPase H+ transporting V0 subunit a2*	ENSMUSG00000038023	54
Tcirg1 / T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 / Q13488* / T cell immune regulator 1, ATPase H+ transporting V0 subunit a3*	ENSMUSG00000001750	48

Protein motifs (from Interpro)

Interpro ID	Name
IPR002490	V-type ATPase, V0 complex, 116kDa subunit family
IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0007035	vacuolar acidification	IBA
biological_process	GO:0015986	ATP synthesis coupled proton transport	IBA
biological_process	GO:0015991	ATP hydrolysis coupled proton transport	IEA
biological_process	GO:0016241	regulation of macroautophagy	ISO
biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	IBA
biological_process	GO:1901998	toxin transport	IMP
cellular_component	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	IBA
cellular_component	GO:0016607	nuclear speck	ISO
cellular_component	GO:0030659	cytoplasmic vesicle membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0033179	proton-transporting V-type ATPase, V0 domain	IEA
cellular_component	GO:0042470	melanosome	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015078	proton transmembrane transporter activity	IEA
molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	IBA
molecular_function	GO:0051117	ATPase binding	IBA

Pathways (from Reactome)

Pathway description

ROS, RNS production in phagocytes

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005385	cardiovascular system phenotype		Show Allelic Composition: Atp1a3^{tm1b(EUCOMM)Hmgu}/Atp1a3⁺ Genetic Background: C57BL/6N-Atp1a3^{tm1b(EUCOMM)Hmgu}/H
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atp1a3^{tm1b(EUCOMM)Hmgu}/Atp1a3⁺ Genetic Background: C57BL/6N-Atp1a3^{tm1b(EUCOMM)Hmgu}/H
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Atp1a3^{tm1b(EUCOMM)Hmgu}/Atp1a3⁺ Genetic Background: C57BL/6N-Atp1a3^{tm1b(EUCOMM)Hmgu}/H
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Atp1a3^{tm1b(EUCOMM)Hmgu}/Atp1a3⁺ Genetic Background: C57BL/6N-Atp1a3^{tm1b(EUCOMM)Hmgu}/H
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Atp1a3^{tm1b(EUCOMM)Hmgu}/Atp1a3⁺ Genetic Background: C57BL/6N-Atp1a3^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000038023	P15920 / Atp6v0a2 / V-type proton ATPase 116 kDa subunit a isoform 2 / Q9Y487* / ATPase H+ transporting V0 subunit a2*	/ complex
ENSMUSG00000038600	Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*	/ complex
ENSMUSG00000001750	Tcirg1 / T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 / Q13488* / T cell immune regulator 1, ATPase H+ transporting V0 subunit a3*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr