ENSMUSG00000001750


Mus musculus

Features
Gene ID: ENSMUSG00000001750
  
Biological name :Tcirg1
  
Synonyms : T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 / Tcirg1
  
Possible biological names infered from orthology : Q13488 / T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 3896050
Gene end: 3907133
  
Corresponding Affymetrix probe sets: 10464529 (MoGene1.0st)   1420635_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122474
Ensembl peptide - ENSMUSP00000120968
Ensembl peptide - ENSMUSP00000121241
Ensembl peptide - ENSMUSP00000001801
Ensembl peptide - ENSMUSP00000114768
Ensembl peptide - ENSMUSP00000120531
NCBI entrez gene - 27060     See in Manteia.
MGI - MGI:1350931
RefSeq - XM_011248632
RefSeq - NM_001136091
RefSeq - NM_001167784
RefSeq - NM_016921
RefSeq Peptide - NP_001161256
RefSeq Peptide - NP_001129563
RefSeq Peptide - NP_058617
swissprot - Q9JHF5
swissprot - F6ZFB8
swissprot - D6RFN1
swissprot - F6XRE6
Ensembl - ENSMUSG00000001750
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcirg1aENSDARG00000016835Danio rerio
 tcirg1bENSDARG00000105142Danio rerio
 TCIRG1ENSGALG00000036069Gallus gallus
 Q13488ENSG00000110719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P15920 / Atp6v0a2 / V-type proton ATPase 116 kDa subunit a isoform 2 / Q9Y487* / ATPase H+ transporting V0 subunit a2*ENSMUSG0000003802353
Q9Z1G4 / Atp6v0a1 / ATPase, H+ transporting, lysosomal V0 subunit A1 / Q93050* / ATPase H+ transporting V0 subunit a1*ENSMUSG0000001930248
Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*ENSMUSG0000003860047


Protein motifs (from Interpro)
Interpro ID Name
 IPR002490  V-type ATPase, V0 complex, 116kDa subunit family
 IPR026028  ATPase, V0 complex, subunit 116kDa, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007035 vacuolar acidification IBA
 biological_processGO:0007039 protein catabolic process in the vacuole IMP
 biological_processGO:0015986 ATP synthesis coupled proton transport IBA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IBA
 cellular_componentGO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0016471 vacuolar proton-transporting V-type ATPase complex IBA
 cellular_componentGO:0033179 proton-transporting V-type ATPase, V0 domain IEA
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IBA
 molecular_functionGO:0051117 ATPase binding IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Neutrophil degranulation
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0000064 failure of secondary bone resorption "inability of osteoclasts to degrade the organic and inorganic phases of bone by absorption" [J:67040, J:61295]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ceacam1tm1.1Fta/Ceacam1tm1.1Fta
Genetic Background: C57BL/6(FVB)-Ceacam1tm1.1Fta

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ppargtm1Uls/Ppargtm1Uls
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Uls/Ppargtm1Uls
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fancmtm1.1Htr/Fancmtm1.1Htr
Genetic Background: involves: C57BL/6 * FVB

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002360 abnormal spleen B cell corona morphology "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Tcirg1oc/Tcirg1oc
Genetic Background: C57BL/6J-Vps33abf

 MP:0008463 abnormal peripheral lymph node morphology "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1M1Jeau/Tcirg1+
Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

 MP:0010969 absent compact bone "absence of the outer layers of solid, hard bone that covers spongy bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

 MP:0012336 decreased vitamin D level "reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030543 abnormal predentin morphology "any structural anomaly of the initial type I collagen-rich unmineralized extracellular matrix synthesized and secreted by odontoblasts and located at the dentin-pulp interface; predentin is converted to dentin when hydroxyapatite crystals are deposited on the predentin" [https://books.google.com/books?isbn=0470958332]
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Allelic Composition: Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038023 P15920 / Atp6v0a2 / V-type proton ATPase 116 kDa subunit a isoform 2 / Q9Y487* / ATPase H+ transporting V0 subunit a2*  / complex
 ENSMUSG00000038600 Q920R6 / Atp6v0a4 / ATPase, H+ transporting, lysosomal V0 subunit A4 / Q9HBG4* / ATPase H+ transporting V0 subunit a4*  / complex
 ENSMUSG00000019302 Q9Z1G4 / Atp6v0a1 / ATPase, H+ transporting, lysosomal V0 subunit A1 / Q93050* / ATPase H+ transporting V0 subunit a1*  / complex






 

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