ENSMUSG00000038486


Mus musculus

Features
Gene ID: ENSMUSG00000038486
  
Biological name :Sv2a
  
Synonyms : Q9JIS5 / Sv2a / Synaptic vesicle glycoprotein 2A
  
Possible biological names infered from orthology : Q7L0J3
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96181151
Gene end: 96195521
  
Corresponding Affymetrix probe sets: 10494372 (MoGene1.0st)   1423406_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037576
NCBI entrez gene - 64051     See in Manteia.
MGI - MGI:1927139
RefSeq - NM_022030
RefSeq Peptide - NP_071313
swissprot - Q9JIS5
Ensembl - ENSMUSG00000038486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sv2aENSDARG00000059945Danio rerio
 SV2AENSG00000159164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sv2c / Q69ZS6 / synaptic vesicle glycoprotein 2c / Q496J9*ENSMUSG0000005111163
Sv2b / Q8BG39 / Synaptic vesicle glycoprotein 2B / Q7L1I2*ENSMUSG0000005302559
Svop / Q8BFT9 / Synaptic vesicle 2-related protein / Q8N4V2* / SV2 related protein*ENSMUSG0000004207818
Svopl / Q6PDF3 / Putative transporter SVOPL / Q8N434* / SVOP like*ENSMUSG0000002983016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001646  Pentapeptide repeat
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR022308  Synaptic vesicle protein SV2
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0014052 regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048786 presynaptic active zone IDA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj,Svoptm1.1Baj/Svoptm1.1Baj
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud,Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2a+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud,Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj
Genetic Background: involves: 129 * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: either: (129S4/SvJae-Inhbbtm1Jae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud,Sv2btm1Sud/Sv2btm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sv2atm1Baj/Sv2atm1Baj,Sv2btm1Baj/Sv2btm1Baj,Svoptm1.1Baj/Svoptm1.1Baj
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Sv2atm1Sud/Sv2atm1Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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