ENSMUSG00000038612


Mus musculus

Features
Gene ID: ENSMUSG00000038612
  
Biological name :Mcl1
  
Synonyms : Induced myeloid leukemia cell differentiation / Mcl1 / P97287
  
Possible biological names infered from orthology : MCL1, BCL2 family apoptosis regulator / Q07820
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 95658788
Gene end: 95663176
  
Corresponding Affymetrix probe sets: 10494306 (MoGene1.0st)   1416880_at (Mouse Genome 430 2.0 Array)   1416881_at (Mouse Genome 430 2.0 Array)   1437527_x_at (Mouse Genome 430 2.0 Array)   1448503_at (Mouse Genome 430 2.0 Array)   1456243_x_at (Mouse Genome 430 2.0 Array)   1456381_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044048
Ensembl peptide - ENSMUSP00000135915
NCBI entrez gene - 17210     See in Manteia.
MGI - MGI:101769
RefSeq - XM_006501088
RefSeq - NM_008562
RefSeq Peptide - NP_032588
swissprot - P97287
Ensembl - ENSMUSG00000038612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcl1aENSDARG00000009779Danio rerio
 mcl1bENSDARG00000008363Danio rerio
 MCL1ENSGALG00000044383Gallus gallus
 MCL1ENSG00000143384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR013281  Apoptosis regulator, Mcl-1
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0010507 negative regulation of autophagy ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034097 response to cytokine ISO
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:2000811 negative regulation of anoikis ISO
 biological_processGO:2001020 regulation of response to DNA damage stimulus ISO
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0051434 BH3 domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Mcl1tm1Ywh/Mcl1tm1Ywh
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprv+
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen
Genetic Background: B6.129-Mcl1tm1Yen

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen
Genetic Background: B6.129-Mcl1tm1Yen

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005433 deficiency of early pro-B cells "lack of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005434 deficiency of late pro-B cells "lack of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm3.1Ksk/Esr1tm3.1Ksk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Mcl1tm1Ywh/Mcl1tm1Ywh
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen
Genetic Background: B6.129-Mcl1tm1Yen

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Yen/Mcl1tm1Yen
Genetic Background: B6.129-Mcl1tm1Yen

 MP:0008094 absent memory B cells "absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008185 decreased naive B cell number "reduced number of mature B cells which have not yet been activated by antigen" [CL:0000788, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1tm1Dmta,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008729 decreased memory B cell number "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009666 abnormal embryo attachment "any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
Show

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr