ENSG00000143384


Homo sapiens

Features
Gene ID: ENSG00000143384
  
Biological name :MCL1
  
Synonyms : MCL1 / MCL1, BCL2 family apoptosis regulator / Q07820
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.2
Gene start: 150574551
Gene end: 150579738
  
Corresponding Affymetrix probe sets: 200796_s_at (Human Genome U133 Plus 2.0 Array)   200797_s_at (Human Genome U133 Plus 2.0 Array)   200798_x_at (Human Genome U133 Plus 2.0 Array)   214056_at (Human Genome U133 Plus 2.0 Array)   214057_at (Human Genome U133 Plus 2.0 Array)   227175_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477624
Ensembl peptide - ENSP00000309973
Ensembl peptide - ENSP00000358022
NCBI entrez gene - 4170     See in Manteia.
OMIM - 159552
RefSeq - NM_001197320
RefSeq - NM_021960
RefSeq - NM_182763
RefSeq Peptide - NP_001184249
RefSeq Peptide - NP_068779
RefSeq Peptide - NP_877495
swissprot - Q07820
swissprot - A0A087WT64
Ensembl - ENSG00000143384
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcl1aENSDARG00000009779Danio rerio
 mcl1bENSDARG00000008363Danio rerio
 MCL1ENSGALG00000044383Gallus gallus
 Mcl1ENSMUSG00000038612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR013281  Apoptosis regulator, Mcl-1
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination NAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019725 cellular homeostasis NAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0071806 protein transmembrane transport IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IGI
 biological_processGO:2000811 negative regulation of anoikis IMP
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008320 protein transmembrane transporter activity TAS
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051434 BH3 domain binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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