ENSMUSG00000038914


Mus musculus

Features
Gene ID: ENSMUSG00000038914
  
Biological name :Dido1
  
Synonyms : Death-inducer obliterator 1 / Dido1 / Q8C9B9
  
Possible biological names infered from orthology : Q9BTC0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 180657964
Gene end: 180709999
  
Corresponding Affymetrix probe sets: 10490510 (MoGene1.0st)   1431258_at (Mouse Genome 430 2.0 Array)   1437182_at (Mouse Genome 430 2.0 Array)   1437647_at (Mouse Genome 430 2.0 Array)   1456405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119689
Ensembl peptide - ENSMUSP00000099345
Ensembl peptide - ENSMUSP00000099346
Ensembl peptide - ENSMUSP00000048315
Ensembl peptide - ENSMUSP00000084794
Ensembl peptide - ENSMUSP00000099344
NCBI entrez gene - 23856     See in Manteia.
MGI - MGI:1344352
RefSeq - XM_006500616
RefSeq - NM_001291432
RefSeq - NM_001291433
RefSeq - NM_011805
RefSeq - NM_175551
RefSeq - NM_177852
RefSeq - XM_006500608
RefSeq - XM_006500609
RefSeq - XM_006500610
RefSeq - XM_006500611
RefSeq - XM_006500612
RefSeq - XM_006500615
RefSeq Peptide - NP_035935
RefSeq Peptide - NP_001278361
RefSeq Peptide - NP_001278362
RefSeq Peptide - NP_780760
RefSeq Peptide - NP_808520
swissprot - A0A0R4J0L7
swissprot - Q8C9B9
Ensembl - ENSMUSG00000038914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dido1ENSDARG00000057940Danio rerio
 si:ch73-181d5.4ENSDARG00000057907Danio rerio
 ENSGALG00000039201Gallus gallus
 ENSGALG00000005652Gallus gallus
 ENSGALG00000044211Gallus gallus
 DIDO1ENSG00000101191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf3 / PHD finger protein 3 / Q92576*ENSMUSG0000004887420
Spocd1 / Q6ZMY3* / SPOC domain containing 1*ENSMUSG000000287848


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003618  Transcription elongation factor S-II, central domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR012921  Spen paralogue and orthologue SPOC, C-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR033082  Death-inducer obliterator 1
 IPR036575  Transcription elongation factor S-II, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6tm1Mur/Il6+
Genetic Background: B6.129P2(B6)-Il6tm1Mur

Allelic Composition: Dido1tm1Cmar/Dido1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

 MP:0011192 decreased embryonic epiblast cell proliferation "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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