Manteia

ENSMUSG00000039000

Mus musculus

Features

Gene ID:	ENSMUSG00000039000

Biological name :	Ube3c

Synonyms :	Q80U95 / Ube3c / ubiquitin protein ligase E3C

Possible biological names infered from orthology :	Q15386

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	B1
Gene start:	29569242
Gene end:	29676092

Corresponding Affymetrix probe sets:	10520419 (MoGene1.0st) 1426881_at (Mouse Genome 430 2.0 Array) 1426882_at (Mouse Genome 430 2.0 Array) 1456992_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000142474 Ensembl peptide - ENSMUSP00000045998 NCBI entrez gene - 100763 See in Manteia. MGI - MGI:2140998 RefSeq - NM_133907 RefSeq Peptide - NP_598668 swissprot - A0A0G2JDR9 swissprot - Q80U95 Ensembl - ENSMUSG00000039000

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ube3c	ENSDARG00000035978	Danio rerio
UBE3C	ENSGALG00000006461	Gallus gallus
UBE3C	ENSG00000009335	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ube3b / Q9ES34 / ubiquitin protein ligase E3B / Q7Z3V4*	ENSMUSG00000029577	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000048	IQ motif, EF-hand binding site
IPR000569	HECT domain
IPR035983	HECT, E3 ligase catalytic domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000209	protein polyubiquitination	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IBA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	ISO
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IBA

Pathways (from Reactome)

Pathway description

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0005387	immune system phenotype		Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0010850	increased effector memory CD8-positive, alpha-beta T cell number	"increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0011942	decreased fluid intake	"reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013513	decreased memory-marker CD4-negative NK T cell number	"reduction in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013519	decreased CD4-positive NK T cell number	"reduction in the number of CD4-positive NK T cells" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013522	decreased memory-marker CD4-positive NK T cell number	"reduction in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013678	decreased Ly6C-positive NK T cell number	"reduction in the number of NK T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013679	increased Ly6C-positive NK T cell number	"increase in the number of NK T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H
MP:0013691	decreased CD5-positive Ly6C-positive T cell number	"reduction in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Txnip^{tm1b(EUCOMM)Hmgu}/Txnip^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Txnip^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr