ENSMUSG00000029577


Mus musculus

Features
Gene ID: ENSMUSG00000029577
  
Biological name :Ube3b
  
Synonyms : Q9ES34 / Ube3b / ubiquitin protein ligase E3B
  
Possible biological names infered from orthology : Q7Z3V4
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 114380607
Gene end: 114421169
  
Corresponding Affymetrix probe sets: 10524525 (MoGene1.0st)   1452149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143455
Ensembl peptide - ENSMUSP00000073652
Ensembl peptide - ENSMUSP00000138723
Ensembl peptide - ENSMUSP00000142943
NCBI entrez gene - 117146     See in Manteia.
MGI - MGI:1891295
RefSeq - XM_011248161
RefSeq - NM_001331219
RefSeq - NM_054093
RefSeq - XM_006530126
RefSeq Peptide - NP_001318148
RefSeq Peptide - NP_473434
swissprot - Q9ES34
swissprot - A0A0G2JG76
swissprot - S4R2P2
swissprot - A0A0G2JEX8
Ensembl - ENSMUSG00000029577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube3bENSDARG00000061960Danio rerio
 UBE3BENSGALG00000013851Gallus gallus
 UBE3BENSG00000151148Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube3c / Q80U95 / ubiquitin protein ligase E3C / Q15386*ENSMUSG0000003900028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000569  HECT domain
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006188 retinal calcification "pathologic deposition of calcium salts in the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012460 decreased dentate gyrus size "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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