ENSMUSG00000039236


Mus musculus

Features
Gene ID: ENSMUSG00000039236
  
Biological name :Isg20
  
Synonyms : Interferon-stimulated 20 kDa protein / Isg20 / Q9JL16
  
Possible biological names infered from orthology : interferon stimulated exonuclease gene 20 / Q96AZ6
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D2
Gene start: 78913424
Gene end: 78920396
  
Corresponding Affymetrix probe sets: 10554240 (MoGene1.0st)   1419569_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112480
Ensembl peptide - ENSMUSP00000113255
Ensembl peptide - ENSMUSP00000145840
Ensembl peptide - ENSMUSP00000040080
Ensembl peptide - ENSMUSP00000112621
NCBI entrez gene - 57444     See in Manteia.
MGI - MGI:1928895
RefSeq - XM_006541028
RefSeq - NM_001113527
RefSeq - NM_001291220
RefSeq - NM_001291221
RefSeq - NM_020583
RefSeq - XM_006541026
RefSeq Peptide - NP_001278150
RefSeq Peptide - NP_065608
RefSeq Peptide - NP_001106999
RefSeq Peptide - NP_001278149
swissprot - Q4FK39
swissprot - Q9JL16
swissprot - A0A0U1RP59
Ensembl - ENSMUSG00000039236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISG20ENSG00000172183Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aen / Q9CZI9 / Apoptosis-enhancing nuclease / Q8WTP8*ENSMUSG0000003060928
Isg20l2 / interferon stimulated exonuclease gene 20 like 2 / Q9H9L3*ENSMUSG0000004803924
Rexo4 / Q6PAQ4 / RNA exonuclease 4 / Q9GZR2* / REX4 homolog, 3-5 exonuclease*ENSMUSG0000005240620


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000738 DNA catabolic process, exonucleolytic ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006401 RNA catabolic process ISO
 biological_processGO:0009615 response to virus ISO
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0015030 Cajal body ISS
 cellular_componentGO:0016605 PML body ISO
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity ISO
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity ISO
 molecular_functionGO:0008859 exoribonuclease II activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030619 U1 snRNA binding ISO
 molecular_functionGO:0030620 U2 snRNA binding ISS
 molecular_functionGO:0034511 U3 snoRNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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