ENSG00000172183


Homo sapiens

Features
Gene ID: ENSG00000172183
  
Biological name :ISG20
  
Synonyms : interferon stimulated exonuclease gene 20 / ISG20 / Q96AZ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 88636153
Gene end: 88656483
  
Corresponding Affymetrix probe sets: 204698_at (Human Genome U133 Plus 2.0 Array)   33304_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306565
Ensembl peptide - ENSP00000368526
Ensembl peptide - ENSP00000453638
Ensembl peptide - ENSP00000453666
NCBI entrez gene - 3669     See in Manteia.
OMIM - 604533
RefSeq - XM_017022148
RefSeq - NM_001303233
RefSeq - NM_001303234
RefSeq - NM_001303236
RefSeq - NM_001303237
RefSeq - NM_002201
RefSeq - XM_005254899
RefSeq - XM_006720488
RefSeq Peptide - NP_001290162
RefSeq Peptide - NP_001290166
RefSeq Peptide - NP_002192
RefSeq Peptide - NP_001290163
RefSeq Peptide - NP_001290165
swissprot - H3BLY5
swissprot - H0YMM4
swissprot - Q96AZ6
Ensembl - ENSG00000172183
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Isg20ENSMUSG00000039236Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AEN / Q8WTP8 / apoptosis enhancing nucleaseENSG0000018102651
Q9H9L3 / ISG20L2 / interferon stimulated exonuclease gene 20 like 2ENSG0000014331946
REXO4 / Q9GZR2 / REX4 homolog, 3-5 exonucleaseENSG0000014830035


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000738 DNA catabolic process, exonucleolytic IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006401 RNA catabolic process IDA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016605 PML body IDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IMP
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity IDA
 molecular_functionGO:0008859 exoribonuclease II activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030619 U1 snRNA binding IDA
 molecular_functionGO:0030620 U2 snRNA binding IDA
 molecular_functionGO:0034511 U3 snoRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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