ENSG00000143319


Homo sapiens

Features
Gene ID: ENSG00000143319
  
Biological name :ISG20L2
  
Synonyms : interferon stimulated exonuclease gene 20 like 2 / ISG20L2 / Q9H9L3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.1
Gene start: 156721891
Gene end: 156728799
  
Corresponding Affymetrix probe sets: 208114_s_at (Human Genome U133 Plus 2.0 Array)   212766_s_at (Human Genome U133 Plus 2.0 Array)   216502_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000323424
Ensembl peptide - ENSP00000357202
NCBI entrez gene - 81875     See in Manteia.
OMIM - 611930
RefSeq - XM_006711561
RefSeq - NM_001303095
RefSeq - XM_005245516
RefSeq - XM_006711560
RefSeq Peptide - NP_001290024
swissprot - Q9H9L3
Ensembl - ENSG00000143319
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isg20l2ENSDARG00000102266Danio rerio
 Isg20l2ENSMUSG00000048039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AEN / Q8WTP8 / apoptosis enhancing nucleaseENSG0000018102636
REXO4 / Q9GZR2 / REX4 homolog, 3-5 exonucleaseENSG0000014830026
ISG20 / Q96AZ6 / interferon stimulated exonuclease gene 20ENSG0000017218324


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR034933  Interferon-stimulated 20kDa exonuclease-like 2
 IPR036397  Ribonuclease H superfamily
 IPR037433  ISG20, DEDDh 3"-5" exonuclease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity EXP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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