ENSG00000181026


Homo sapiens

Features
Gene ID: ENSG00000181026
  
Biological name :AEN
  
Synonyms : AEN / apoptosis enhancing nuclease / Q8WTP8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 88621296
Gene end: 88632282
  
Corresponding Affymetrix probe sets: 219361_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331944
Ensembl peptide - ENSP00000453631
NCBI entrez gene - 64782     See in Manteia.
OMIM - 610177
RefSeq - XM_017022489
RefSeq - NM_022767
RefSeq - XM_005254967
RefSeq - XM_006720645
RefSeq - XM_011521905
RefSeq - XM_005254966
RefSeq Peptide - NP_073604
swissprot - Q8WTP8
swissprot - H0YMJ6
Ensembl - ENSG00000181026
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isg20ENSDARG00000079783Danio rerio
 AENENSGALG00000044204Gallus gallus
 AenENSMUSG00000030609Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H9L3 / ISG20L2 / interferon stimulated exonuclease gene 20 like 2ENSG0000014331939
ISG20 / Q96AZ6 / interferon stimulated exonuclease gene 20ENSG0000017218328
REXO4 / Q9GZR2 / REX4 homolog, 3-5 exonucleaseENSG0000014830026


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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