ENSMUSG00000039316


Mus musculus

Features
Gene ID: ENSMUSG00000039316
  
Biological name :Rftn1
  
Synonyms : Q6A0D4 / Raftlin / Rftn1
  
Possible biological names infered from orthology : Q14699 / raftlin, lipid raft linker 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 49992257
Gene end: 50190674
  
Corresponding Affymetrix probe sets: 10451710 (MoGene1.0st)   1428696_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108820
Ensembl peptide - ENSMUSP00000046524
NCBI entrez gene - 76438     See in Manteia.
MGI - MGI:1923688
RefSeq - NM_181397
RefSeq - XM_006525081
RefSeq Peptide - NP_852062
swissprot - D3Z731
swissprot - Q6A0D4
Ensembl - ENSMUSG00000039316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ976914.1ENSDARG00000098654Danio rerio
 rftn1aENSDARG00000070831Danio rerio
 RFTN1ENSGALG00000011241Gallus gallus
 RFTN1ENSG00000131378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rftn2 / Q8CHX7 / Raftlin-2 / Q52LD8* / raftlin family member 2*ENSMUSG0000002597826


Protein motifs (from Interpro)
Interpro ID Name
 IPR028169  Raftlin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly IEA
 biological_processGO:0002457 T cell antigen processing and presentation IMP
 biological_processGO:0032596 protein transport into membrane raft IMP
 biological_processGO:0032620 interleukin-17 production IMP
 biological_processGO:0033227 dsRNA transport IEA
 biological_processGO:0034138 toll-like receptor 3 signaling pathway ISO
 biological_processGO:0040007 growth IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:1903044 protein localization to membrane raft IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045121 membrane raft IBA
 molecular_functionGO:0003725 double-stranded RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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