ENSMUSG00000039396


Mus musculus

Features
Gene ID: ENSMUSG00000039396
  
Biological name :Neil3
  
Synonyms : Endonuclease 8-like 3 / Neil3 / Q8K203
  
Possible biological names infered from orthology : nei like DNA glycosylase 3 / Q8TAT5
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B1.3
Gene start: 53586867
Gene end: 53639065
  
Corresponding Affymetrix probe sets: 10578690 (MoGene1.0st)   1424060_at (Mouse Genome 430 2.0 Array)   1440633_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121938
Ensembl peptide - ENSMUSP00000041909
NCBI entrez gene - 234258     See in Manteia.
MGI - MGI:2384588
RefSeq - NM_146208
RefSeq Peptide - NP_666320
swissprot - D3Z1T7
swissprot - Q8K203
Ensembl - ENSMUSG00000039396
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neil3ENSDARG00000020079Danio rerio
 NEIL3ENSG00000109674Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Neil2 / Q6R2P8 / Endonuclease 8-like 2 / Q969S2* / nei like DNA glycosylase 2*ENSMUSG0000003512112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000214  Zinc finger, DNA glycosylase/AP lyase-type
 IPR001876  Zinc finger, RanBP2-type
 IPR010666  Zinc finger, GRF-type
 IPR010979  Ribosomal protein S13-like, H2TH
 IPR012319  Formamidopyrimidine-DNA glycosylase, catalytic domain
 IPR015886  DNA glycosylase/AP lyase, H2TH DNA-binding
 IPR015887  DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site
 IPR035937  MutM-like, N-terminal
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000405 bubble DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Apctm1.1Alew/Apctm1.1Alew
Genetic Background: B6.129-Apctm1.1Alew

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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