ENSMUSG00000039463


Mus musculus

Features
Gene ID: ENSMUSG00000039463
  
Biological name :Slc9a8
  
Synonyms : Q8R4D1 / Slc9a8 / Sodium/hydrogen exchanger 8
  
Possible biological names infered from orthology : Q9Y2E8 / solute carrier family 9 member A8
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 167421712
Gene end: 167477000
  
Corresponding Affymetrix probe sets: 10478854 (MoGene1.0st)   1426274_at (Mouse Genome 430 2.0 Array)   1430932_at (Mouse Genome 430 2.0 Array)   1431205_at (Mouse Genome 430 2.0 Array)   1454865_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044185
Ensembl peptide - ENSMUSP00000073536
Ensembl peptide - ENSMUSP00000104841
NCBI entrez gene - 77031     See in Manteia.
MGI - MGI:1924281
RefSeq - XM_006500400
RefSeq - NM_001304540
RefSeq - NM_001304542
RefSeq - NM_148929
RefSeq - XM_006500395
RefSeq - XM_006500399
RefSeq Peptide - NP_683731
RefSeq Peptide - NP_001291469
RefSeq Peptide - NP_001291471
swissprot - Q8R4D1
swissprot - A2A464
Ensembl - ENSMUSG00000039463
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc9a8ENSDARG00000020699Danio rerio
 SLC9A8ENSGALG00000008045Gallus gallus
 Q9Y2E8ENSG00000197818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BLV3 / Slc9a7 / Sodium/hydrogen exchanger 7 / Q96T83* / solute carrier family 9 member A7*ENSMUSG0000003734132
Q8BZ00 / Slc9a9 / Sodium/hydrogen exchanger 9 / Q8IVB4* / solute carrier family 9 member A9*ENSMUSG0000003112932
Slc9a6 / Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 6 (Slc9a6), transcript variant 2, mRNA. / Q92581* / solute carrier family 9 member A6*ENSMUSG0000006068131
Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*ENSMUSG0000002885426
G3X939 / Slc9a3 / Sodium/hydrogen exchanger 3 / P48764* / solute carrier family 9 member A3*ENSMUSG0000003612325
Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger), member 2 / Q9UBY0* / solute carrier family 9 member A2*ENSMUSG0000002606225
Slc9a5 / solute carrier family 9 (sodium/hydrogen exchanger), member 5 / Q14940* / solute carrier family 9 member A5*ENSMUSG0000001478625
Q8BUE1 / Slc9a4 / Sodium/hydrogen exchanger 4 / Q6AI14* / solute carrier family 9 member A4*ENSMUSG0000002606524


Protein motifs (from Interpro)
Interpro ID Name
 IPR004709  Na+/H+ exchanger
 IPR006153  Cation/H+ exchanger
 IPR018409  Na+/H+ exchanger, isoform 8
 IPR018422  Cation/H+ exchanger, CPA1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0006814 sodium ion transport IDA
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0051453 regulation of intracellular pH IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015299 solute:proton antiporter activity IEA
 molecular_functionGO:0015385 sodium:proton antiporter activity IDA
 molecular_functionGO:0015386 potassium:proton antiporter activity IDA


Pathways (from Reactome)
Pathway description
Sodium/Proton exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc38a10tm1a(EUCOMM)Wtsi/Slc38a10tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slc38a10tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc38a10tm1a(EUCOMM)Wtsi/Slc38a10tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slc38a10tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc38a10tm1a(EUCOMM)Wtsi/Slc38a10tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slc38a10tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013481 abnormal ileum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [MGI:Anna]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
Show

Allelic Composition: Trp53tm3.1Holl/Trp53tm3.1Holl,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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