ENSMUSG00000026065


Mus musculus

Features
Gene ID: ENSMUSG00000026065
  
Biological name :Slc9a4
  
Synonyms : Q8BUE1 / Slc9a4 / Sodium/hydrogen exchanger 4
  
Possible biological names infered from orthology : Q6AI14 / solute carrier family 9 member A4
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40580081
Gene end: 40630725
  
Corresponding Affymetrix probe sets: 10345840 (MoGene1.0st)   1442915_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027233
NCBI entrez gene - 110895     See in Manteia.
MGI - MGI:105074
RefSeq - XM_006495626
RefSeq - NM_177084
RefSeq - XM_006495625
RefSeq Peptide - NP_796058
swissprot - Q8BUE1
Ensembl - ENSMUSG00000026065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc9a2ENSDARG00000058780Danio rerio
 SLC9A4ENSGALG00000037439Gallus gallus
 Q6AI14ENSG00000180251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger), member 2 / Q9UBY0* / solute carrier family 9 member A2*ENSMUSG0000002606254
Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*ENSMUSG0000002885438
G3X939 / Slc9a3 / Sodium/hydrogen exchanger 3 / P48764* / solute carrier family 9 member A3*ENSMUSG0000003612334
Slc9a5 / solute carrier family 9 (sodium/hydrogen exchanger), member 5 / Q14940* / solute carrier family 9 member A5*ENSMUSG0000001478633
Q8BLV3 / Slc9a7 / Sodium/hydrogen exchanger 7 / Q96T83* / solute carrier family 9 member A7*ENSMUSG0000003734120
Slc9a6 / Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 6 (Slc9a6), transcript variant 2, mRNA. / Q92581* / solute carrier family 9 member A6*ENSMUSG0000006068119
Q8BZ00 / Slc9a9 / Sodium/hydrogen exchanger 9 / Q8IVB4* / solute carrier family 9 member A9*ENSMUSG0000003112918
Q8R4D1 / Slc9a8 / Sodium/hydrogen exchanger 8 / Q9Y2E8* / solute carrier family 9 member A8*ENSMUSG0000003946318


Protein motifs (from Interpro)
Interpro ID Name
 IPR001953  Na+/H+ exchanger, isoform 2 (NHE2)
 IPR004709  Na+/H+ exchanger
 IPR006153  Cation/H+ exchanger
 IPR018422  Cation/H+ exchanger, CPA1 family
 IPR032103  Sodium/hydrogen exchanger, regulatory region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IMP
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0098719 sodium ion import across plasma membrane IBA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015299 solute:proton antiporter activity IEA
 molecular_functionGO:0015385 sodium:proton antiporter activity IBA
 molecular_functionGO:0015386 potassium:proton antiporter activity IBA


Pathways (from Reactome)
Pathway description
Sodium/Proton exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0001653 gastric necrosis "pathologic death of cells within, or a portion of, the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0004138 abnormal mucous neck cell morphology "malformation of the mucin-producing epithelial cells present in the the neck of the gastric glands " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0008001 hypochlorhydria "reduced hydrochloric acid content of the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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