ENSMUSG00000060681


Mus musculus

Features
Gene ID: ENSMUSG00000060681
  
Biological name :Slc9a6
  
Synonyms : Mus musculus solute carrier family 9 (sodium/hydrogen exchanger), member 6 (Slc9a6), transcript variant 2, mRNA. / Slc9a6
  
Possible biological names infered from orthology : Q92581 / solute carrier family 9 member A6
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A6
Gene start: 56609757
Gene end: 56664230
  
Corresponding Affymetrix probe sets: 10599719 (MoGene1.0st)   1435008_at (Mouse Genome 430 2.0 Array)   1435009_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076922
Ensembl peptide - ENSMUSP00000147081
Ensembl peptide - ENSMUSP00000115364
Ensembl peptide - ENSMUSP00000110432
NCBI entrez gene - 236794     See in Manteia.
MGI - MGI:2443511
RefSeq - XM_006527980
RefSeq - NM_001358861
RefSeq - NM_172780
RefSeq - XM_006527979
RefSeq Peptide - NP_766368
RefSeq Peptide - NP_001345790
swissprot - D3Z0Q9
swissprot - A1L3P4
swissprot - A0A140LJ55
swissprot - B0QZV3
Ensembl - ENSMUSG00000060681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc9a6aENSDARG00000009209Danio rerio
 slc9a6bENSDARG00000075382Danio rerio
 SLC9A6ENSGALG00000006180Gallus gallus
 Q92581ENSG00000198689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BLV3 / Slc9a7 / Sodium/hydrogen exchanger 7 / Q96T83* / solute carrier family 9 member A7*ENSMUSG0000003734169
Q8BZ00 / Slc9a9 / Sodium/hydrogen exchanger 9 / Q8IVB4* / solute carrier family 9 member A9*ENSMUSG0000003112955
Q8R4D1 / Slc9a8 / Sodium/hydrogen exchanger 8 / Q9Y2E8* / solute carrier family 9 member A8*ENSMUSG0000003946325
Slc9a5 / solute carrier family 9 (sodium/hydrogen exchanger), member 5 / Q14940* / solute carrier family 9 member A5*ENSMUSG0000001478623
Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger), member 2 / Q9UBY0* / solute carrier family 9 member A2*ENSMUSG0000002606223
Q8BUE1 / Slc9a4 / Sodium/hydrogen exchanger 4 / Q6AI14* / solute carrier family 9 member A4*ENSMUSG0000002606522
G3X939 / Slc9a3 / Sodium/hydrogen exchanger 3 / P48764* / solute carrier family 9 member A3*ENSMUSG0000003612321
Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*ENSMUSG0000002885421


Protein motifs (from Interpro)
Interpro ID Name
 IPR002090  Na+/H+ exchanger, isoform 6 (NHE6)
 IPR004709  Na+/H+ exchanger
 IPR006153  Cation/H+ exchanger
 IPR018422  Cation/H+ exchanger, CPA1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0031547 brain-derived neurotrophic factor receptor signaling pathway IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0048675 axon extension ISO
 biological_processGO:0048812 neuron projection morphogenesis ISO
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0051386 regulation of neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060996 dendritic spine development IMP
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0097484 dendrite extension ISO
 biological_processGO:0098719 sodium ion import across plasma membrane IBA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031901 early endosome membrane ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0044308 axonal spine IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane ISO
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015299 solute:proton antiporter activity IEA
 molecular_functionGO:0015385 sodium:proton antiporter activity IEA
 molecular_functionGO:0015386 potassium:proton antiporter activity IBA


Pathways (from Reactome)
Pathway description
Sodium/Proton exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Wnt5atm1.1Tpy/Wnt5atm1.1Tpy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0008269 abnormal hippocampus CA4 region morphology 
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Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0012231 abnormal ganglioside level 
Show

Allelic Composition: Slc9a6tm1Dgen/Y
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

Allelic Composition: Slc9a6tm1Dgen/Slc9a6+
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

 MP:0012779 abnormal brain cholesterol level "aberrant amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith]
Show

Allelic Composition: Slc9a6tm1Dgen/Slc9a6tm1Dgen
Genetic Background: B6.129P2-Slc9a6tm1Dgen/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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