ENSMUSG00000039509


Mus musculus

Features
Gene ID: ENSMUSG00000039509
  
Biological name :Nup133
  
Synonyms : Nuclear pore complex protein Nup133 / Nup133 / Q8R0G9
  
Possible biological names infered from orthology : nucleoporin 133 / Q8WUM0
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 123897123
Gene end: 123949265
  
Corresponding Affymetrix probe sets: 10582599 (MoGene1.0st)   1423787_at (Mouse Genome 430 2.0 Array)   1423788_at (Mouse Genome 430 2.0 Array)   1436816_at (Mouse Genome 430 2.0 Array)   1441235_at (Mouse Genome 430 2.0 Array)   1451111_at (Mouse Genome 430 2.0 Array)   1457542_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048084
NCBI entrez gene - 234865     See in Manteia.
MGI - MGI:2442620
RefSeq - NM_172288
RefSeq Peptide - NP_758492
swissprot - Q8R0G9
Ensembl - ENSMUSG00000039509
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nup133ENSDARG00000010078Danio rerio
 NUP133ENSGALG00000011091Gallus gallus
 NUP133ENSG00000069248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007187  Nucleoporin, Nup133/Nup155-like, C-terminal
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
 biological_processGO:0006325 chromatin organization IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006405 RNA export from nucleus IBA
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0006606 protein import into nucleus IBA
 biological_processGO:0006999 nuclear pore organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0031081 nuclear pore distribution IBA
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IBA
 cellular_componentGO:0000940 condensed chromosome outer kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031080 nuclear pore outer ring IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017056 structural constituent of nuclear pore ISS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Tnftm1Ljo/Tnftm1Ljo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nup133Gt(RRK090)Byg/Nup133mermaid
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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