ENSMUSG00000039639


Mus musculus

Features
Gene ID: ENSMUSG00000039639
  
Biological name :Kcne1
  
Synonyms : Kcne1 / P23299 / Potassium voltage-gated channel subfamily E member 1
  
Possible biological names infered from orthology : A0A087WTH5 / KCNE1B / P15382 / potassium voltage-gated channel subfamily E regulatory subunit 1 / potassium voltage-gated channel subfamily E regulatory subunit 1B
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 92346001
Gene end: 92359468
  
Corresponding Affymetrix probe sets: 10440989 (MoGene1.0st)   1420672_at (Mouse Genome 430 2.0 Array)   1441035_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052248
Ensembl peptide - ENSMUSP00000130866
NCBI entrez gene - 16509     See in Manteia.
MGI - MGI:96673
RefSeq - XM_006522941
RefSeq - NM_008424
RefSeq Peptide - NP_032450
swissprot - P23299
swissprot - Q545H6
Ensembl - ENSMUSG00000039639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000016012Gallus gallus
 KCNE1ENSG00000180509Homo sapiens
 KCNE1BENSG00000276289Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000369  Potassium channel, voltage-dependent, beta subunit, KCNE
 IPR005424  Potassium channel, voltage-dependent, beta subunit, KCNE1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0006487 protein N-linked glycosylation ISS
 biological_processGO:0006493 protein O-linked glycosylation ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0071468 cellular response to acidic pH IEA
 biological_processGO:0071482 cellular response to light stimulus IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IMP
 biological_processGO:0090315 negative regulation of protein targeting to membrane IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1901387 positive regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity ISS
 biological_processGO:1903817 negative regulation of voltage-gated potassium channel activity IEA
 biological_processGO:1903818 positive regulation of voltage-gated potassium channel activity IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity ISS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity ISS
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Phase 3 - rapid repolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000044 absent organ of Corti "absence of the highly specialized epithelium in the floor of the ductus cochlearis " [J:54408]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Kcnq1tm1Apf/Kcnq1tm1Apf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnq1tm1Apf/Kcnq1tm1Apf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002894 abnormal otoliths "malformed crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003349 abnormal circulating renin level "aberrant blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-5tm2Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004334 utricular macular degeneration "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004397 absent cochlear inner hair cells "absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004530 absent outer hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004775 abnormal vestibular dark cell morphology "any structural abnormality in the nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high potassium ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004776 vestibular dark cell degeneration "degeneration or loss of the nonsensory epithelial cells that lie adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

Allelic Composition: Kcne1pkr/Kcne1+
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0004845 absent vestibuloocular reflex "absence of nystagmus or deviation of the eyes in response to stimulation of the vestibular system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006024 collapsed Reissner membrane "the Reissner s membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:37461:]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008308 small scala media "reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Kcne1pkr/Kcne1pkr
Genetic Background: C57BL/10J-Kcne1pkr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038319 Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*  / complex
 ENSMUSG00000039639 Kcne1 / P23299 / Potassium voltage-gated channel subfamily E member 1 / KCNE1B* / P15382* / A0A087WTH5* / potassium voltage-gated channel subfamily E regulatory subunit 1* / potassium volt...  / complex
 ENSMUSG00000009545 Kcnq1 / P97414 / Potassium voltage-gated channel subfamily KQT member 1 / P51787* / potassium voltage-gated channel subfamily Q member 1*  / complex
 ENSMUSG00000039672 Kcne2 / Mus musculus potassium voltage-gated channel, Isk-related subfamily, 2 (Kcne2), transcript variant 2, mRNA. / Q9Y6J6* / potassium voltage-gated channel subfamily E regulatory subunit 2*  / complex






 

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