ENSMUSG00000039672


Mus musculus

Features
Gene ID: ENSMUSG00000039672
  
Biological name :Kcne2
  
Synonyms : Kcne2 / Mus musculus potassium voltage-gated channel, Isk-related subfamily, 2 (Kcne2), transcript variant 2, mRNA.
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily E regulatory subunit 2 / Q9Y6J6
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C4
Gene start: 92292389
Gene end: 92298129
  
Corresponding Affymetrix probe sets: 10436947 (MoGene1.0st)   1449421_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048849
Ensembl peptide - ENSMUSP00000109604
NCBI entrez gene - 246133     See in Manteia.
MGI - MGI:1891123
RefSeq - XM_006523033
RefSeq - NM_001358372
RefSeq - NM_134110
RefSeq Peptide - NP_001345301
RefSeq Peptide - NP_598871
swissprot - A0A0R4J1J2
Ensembl - ENSMUSG00000039672
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNE2ENSGALG00000030793Gallus gallus
 KCNE2ENSG00000159197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000369  Potassium channel, voltage-dependent, beta subunit, KCNE
 IPR005425  Potassium channel, voltage-dependent, beta subunit, KCNE2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IEA
 biological_processGO:0071435 potassium ion export IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction IEA
 biological_processGO:0086005 ventricular cardiac muscle cell action potential IEA
 biological_processGO:0086009 membrane repolarization IEA
 biological_processGO:0086011 membrane repolarization during action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 biological_processGO:1901387 positive regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1901979 regulation of inward rectifier potassium channel activity IEA
 biological_processGO:1902159 regulation of cyclic nucleotide-gated ion channel activity IEA
 biological_processGO:1902259 regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1903817 negative regulation of voltage-gated potassium channel activity IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005251 delayed rectifier potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA


Pathways (from Reactome)
Pathway description
Phase 3 - rapid repolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1Gwab/Kcne2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0003285 gastric hypertrophy "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab
Genetic Background: involves: 129S4/SvJae

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kcne2tm1Gwab/Kcne2+,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0004731 increased circulating gastrin level "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0008001 hypochlorhydria "reduced hydrochloric acid content of the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne2tm1Gwab/Kcne2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008003 achlorhydria "absence of hydrochloric acid in the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1Gwab/Kcne2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0011891 decreased circulating ferritin level "reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0013569 gastric gland hyperplasia "overdevelopment or increased size, usually due to an increased number of cells, of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [MGI:Anna]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0013578 abnormal stomach glandular region morphology "any structural anomaly of the distinct glandular stomach area which in rodents is demarcated from the non-glandular forestomach by the limiting ridge (margo plicatus); the glandular stomach is connected to the small intestine (duodenum); the wall of the glandular stomach consists of, from inside to outside, simple columnar epithelium containing gastric glands, the lamina propria (epithelium and lamina propria form the glandular mucosa), the muscularis mucosae, the submucosa, the muscularis interna and externa (inner circular and outer longitudinal layers of smooth muscle), and the serosa; the gastric glands lined by simple columnar epithelium form deep gastric pits (foveolae) that are perpendicular to the wall of the stomach; three types of gastric glands exist; the cardiac glands, located near the limiting ridge, contain mucous cells; the pyloric glands also contain mucous cells; the fundic glands, which make up the majority of the gastric glands, contain a variety of cells: mucous neck cells, small, basophilic chief cells, and large, round parietal cells with a granular eosinophilic cytoplasm" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/glandular.html, MGI:Anna]
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Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009545 Kcnq1 / P97414 / Potassium voltage-gated channel subfamily KQT member 1 / P51787* / potassium voltage-gated channel subfamily Q member 1*  / complex
 ENSMUSG00000038319 Kcnh2 / potassium voltage-gated channel subfamily H member 2 / Q12809*  / complex
 ENSMUSG00000039639 Kcne1 / P23299 / Potassium voltage-gated channel subfamily E member 1 / KCNE1B* / P15382* / A0A087WTH5* / potassium voltage-gated channel subfamily E regulatory subunit 1* / potassium volt...  / complex
 ENSMUSG00000039672 Kcne2 / Mus musculus potassium voltage-gated channel, Isk-related subfamily, 2 (Kcne2), transcript variant 2, mRNA. / Q9Y6J6* / potassium voltage-gated channel subfamily E regulatory subunit 2*  / complex






 

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