ENSMUSG00000039783


Mus musculus

Features
Gene ID: ENSMUSG00000039783
  
Biological name :Kmo
  
Synonyms : Kmo / Kynurenine 3-monooxygenase / Q91WN4
  
Possible biological names infered from orthology : O15229
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 175620381
Gene end: 175662116
  
Corresponding Affymetrix probe sets: 10352000 (MoGene1.0st)   1418998_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038914
Ensembl peptide - ENSMUSP00000095067
Ensembl peptide - ENSMUSP00000122943
NCBI entrez gene - 98256     See in Manteia.
MGI - MGI:2138151
RefSeq - NM_133809
RefSeq Peptide - NP_598570
swissprot - Q3V0K6
swissprot - Q91WN4
Ensembl - ENSMUSG00000039783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmoENSDARG00000009160Danio rerio
 KMOENSGALG00000007503Gallus gallus
 KMOENSG00000117009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002938  FAD-binding domain
 IPR027545  Kynurenine 3-monooxygenase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006569 tryptophan catabolic process IEA
 biological_processGO:0009435 NAD biosynthetic process IEA
 biological_processGO:0009651 response to salt stress ISO
 biological_processGO:0019363 pyridine nucleotide biosynthetic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine IEA
 biological_processGO:0019674 NAD metabolic process IBA
 biological_processGO:0019805 quinolinate biosynthetic process IEA
 biological_processGO:0044550 secondary metabolite biosynthetic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070189 kynurenine metabolic process IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004502 kynurenine 3-monooxygenase activity ISO
 molecular_functionGO:0016174 NAD(P)H oxidase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IBA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Kmotm1.2Pjmi/Kmotm1.2Pjmi
Genetic Background: FVB.B6(Cg)-Kmotm1.2Pjmi

 MP:0013242 abnormal amino acid metabolism "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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