ENSMUSG00000039953


Mus musculus

Features
Gene ID: ENSMUSG00000039953
  
Biological name :Clstn1
  
Synonyms : Calsyntenin-1 Soluble Alc-alpha CTF1-alpha / Clstn1 / Q9EPL2
  
Possible biological names infered from orthology : calsyntenin 1 / O94985
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 149586468
Gene end: 149648899
  
Corresponding Affymetrix probe sets: 10510482 (MoGene1.0st)   1421860_at (Mouse Genome 430 2.0 Array)   1421861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036962
Ensembl peptide - ENSMUSP00000101316
NCBI entrez gene - 65945     See in Manteia.
MGI - MGI:1929895
RefSeq - XM_006539094
RefSeq - NM_001290989
RefSeq - NM_023051
RefSeq - XM_006539093
RefSeq Peptide - NP_001277918
RefSeq Peptide - NP_075538
swissprot - Q9EPL2
Ensembl - ENSMUSG00000039953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clstn1ENSDARG00000031720Danio rerio
 CLSTN1ENSGALG00000002606Gallus gallus
 CLSTN1ENSG00000171603Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clstn2 / Q9ER65 / Calsyntenin-2 / Q9H4D0*ENSMUSG0000003245251
Clstn3 / Q99JH7 / Mus musculus calsyntenin 3 (Clstn3), transcript variant 2, mRNA. / Q9BQT9* / calsyntenin 3*ENSMUSG0000000815350


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR026914  Calsyntenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0006874 cellular calcium ion homeostasis TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007268 chemical synaptic transmission NAS
 biological_processGO:0050806 positive regulation of synaptic transmission IGI
 biological_processGO:0051965 positive regulation of synapse assembly IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0042988 X11-like protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0011273 prolonged excitatory postsynaptic current decay time 
Show

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr