ENSMUSG00000008153


Mus musculus

Features
Gene ID: ENSMUSG00000008153
  
Biological name :Clstn3
  
Synonyms : Clstn3 / Mus musculus calsyntenin 3 (Clstn3), transcript variant 2, mRNA. / Q99JH7
  
Possible biological names infered from orthology : calsyntenin 3 / Q9BQT9
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124430759
Gene end: 124464794
  
Corresponding Affymetrix probe sets: 10547719 (MoGene1.0st)   1426989_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108142
Ensembl peptide - ENSMUSP00000145422
Ensembl peptide - ENSMUSP00000008297
NCBI entrez gene - 232370     See in Manteia.
MGI - MGI:2178323
RefSeq - NM_153508
RefSeq - XM_006506031
RefSeq - NM_001346656
RefSeq Peptide - NP_001333585
RefSeq Peptide - NP_705728
swissprot - A0A0N4SW90
swissprot - Q99JH7
swissprot - D3Z601
Ensembl - ENSMUSG00000008153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clstn3ENSDARG00000073883Danio rerio
 CLSTN3ENSGALG00000014674Gallus gallus
 CLSTN3ENSG00000139182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clstn1 / Q9EPL2 / Calsyntenin-1 Soluble Alc-alpha CTF1-alpha / O94985* / calsyntenin 1*ENSMUSG0000003995351
Clstn2 / Q9ER65 / Calsyntenin-2 / Q9H4D0*ENSMUSG0000003245247


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR026914  Calsyntenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0050806 positive regulation of synaptic transmission IGI
 biological_processGO:0051932 synaptic transmission, GABAergic IMP
 biological_processGO:0051965 positive regulation of synapse assembly IGI
 biological_processGO:1902474 positive regulation of protein localization to synapse IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011151 abnormal hippocampus stratum radiatum morphology 
Show

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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