ENSMUSG00000040325


Mus musculus

Features
Gene ID: ENSMUSG00000040325
  
Biological name :Dcaf1
  
Synonyms : Dcaf1 / DDB1- and CUL4-associated factor 1 / Q80TR8
  
Possible biological names infered from orthology : Q9Y4B6
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106821874
Gene end: 106880992
  
Corresponding Affymetrix probe sets: 10588547 (MoGene1.0st)   1434609_at (Mouse Genome 430 2.0 Array)   1455764_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060025
Ensembl peptide - ENSMUSP00000123865
Ensembl peptide - ENSMUSP00000125730
Ensembl peptide - ENSMUSP00000131135
NCBI entrez gene - 321006     See in Manteia.
MGI - MGI:2445220
RefSeq - XM_006511754
RefSeq - XM_006511755
RefSeq - NM_001015507
RefSeq - XM_006511753
RefSeq Peptide - NP_001015507
swissprot - Q80TR8
swissprot - F7A803
Ensembl - ENSMUSG00000040325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DCAF1ENSGALG00000033301Gallus gallus
 DCAF1ENSG00000145041Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006594  LIS1 homology motif
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0033151 V(D)J recombination IMP
 biological_processGO:0035212 cell competition in a multicellular organism ISO
 biological_processGO:1990245 histone H2A-T120 phosphorylation ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008180 COP9 signalosome ISO
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:1990244 histone kinase activity (H2A-T120 specific) ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: NOD.Cg-Il21rtm1Wjl

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: NOD.Cg-Il21rtm1Wjl

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: NOD.Cg-Il21rtm1Wjl

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: NOD.Cg-Il21rtm1Wjl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr