ENSMUSG00000040586


Mus musculus

Features
Gene ID: ENSMUSG00000040586
  
Biological name :Ofd1
  
Synonyms : Ofd1 / OFD1, centriole and centriolar satellite protein
  
Possible biological names infered from orthology : O75665
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 166390033
Gene end: 166440704
  
Corresponding Affymetrix probe sets: 10607806 (MoGene1.0st)   1427172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041744
NCBI entrez gene - 237222     See in Manteia.
MGI - MGI:1350328
RefSeq - NM_177429
RefSeq - XM_006528839
RefSeq Peptide - NP_803178
swissprot - A2AEG2
Ensembl - ENSMUSG00000040586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ofd1ENSDARG00000000529Danio rerio
 OFD1ENSGALG00000016576Gallus gallus
 OFD1ENSG00000046651Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006594  LIS1 homology motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060271 cilium assembly IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Hedgehog off state
Anchoring of the basal body to the plasma membrane
Hedgehog on state
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm1Bfra/Ofd1tm1Bfra
Genetic Background: involves: 129S2/SvPas

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ofd1tm1Bfra/Y,Tg(CAG-cre)1Nagy/0
Genetic Background: involves: 129S2/SvPas

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Ofd1tm2.1Bfra/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm2.1Bfra/Ofd1+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL/J

Allelic Composition: Ofd1tm1Bfra/Ofd1tm1Bfra
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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