ENSMUSG00000040680


Mus musculus

Features
Gene ID: ENSMUSG00000040680
  
Biological name :Kremen2
  
Synonyms : Kremen2 / Kremen protein 2 / Q8K1S7
  
Possible biological names infered from orthology : kringle containing transmembrane protein 2 / Q8NCW0
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 23741197
Gene end: 23745833
  
Corresponding Affymetrix probe sets: 10448355 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000046369
NCBI entrez gene - 73016     See in Manteia.
MGI - MGI:1920266
RefSeq - XM_006524984
RefSeq - NM_028416
RefSeq - XM_006524983
RefSeq Peptide - NP_082692
swissprot - Q8K1S7
Ensembl - ENSMUSG00000040680
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8NCW0ENSG00000131650Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99N43 / Kremen1 / Kremen protein 1 / Q96MU8* / kringle containing transmembrane protein 1*ENSMUSG0000002039334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000859  CUB domain
 IPR002889  Carbohydrate-binding WSC
 IPR013806  Kringle-like fold
 IPR017076  Kremen
 IPR018056  Kringle, conserved site
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IBA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0060173 limb development IMP
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Kremen1tm1Dgen/Kremen1tm1Dgen,Kremen2tm1Cni/Kremen2tm1Cni
Genetic Background: either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Kremen1tm1Dgen/Kremen1tm1Dgen,Kremen2tm1Cni/Kremen2tm1Cni
Genetic Background: either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Lin7ctm2Dsb/Lin7ctm2Dsb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024868 Dkk1 / O54908 / Dickkopf-related protein 1 / O94907* / dickkopf WNT signaling pathway inhibitor 1*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex / reaction






 

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