ENSG00000131650


Homo sapiens

Features
Gene ID: ENSG00000131650
  
Biological name :KREMEN2
  
Synonyms : KREMEN2 / kringle containing transmembrane protein 2 / Q8NCW0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 2963944
Gene end: 2968383
  
Corresponding Affymetrix probe sets: 219692_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461860
Ensembl peptide - ENSP00000460578
Ensembl peptide - ENSP00000460917
Ensembl peptide - ENSP00000304422
Ensembl peptide - ENSP00000322079
Ensembl peptide - ENSP00000459878
NCBI entrez gene - 79412     See in Manteia.
OMIM - 609899
RefSeq - NM_001253725
RefSeq - NM_001253726
RefSeq - NM_024507
RefSeq - NM_172229
RefSeq Peptide - NP_001240654
RefSeq Peptide - NP_001240655
RefSeq Peptide - NP_078783
RefSeq Peptide - NP_757384
swissprot - Q8NCW0
Ensembl - ENSG00000131650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8K1S7ENSMUSG00000040680Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96MU8 / KREMEN1 / kringle containing transmembrane protein 1ENSG0000018376235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000859  CUB domain
 IPR002889  Carbohydrate-binding WSC
 IPR013806  Kringle-like fold
 IPR017076  Kremen
 IPR018056  Kringle, conserved site
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IBA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030279 negative regulation of ossification ISS
 biological_processGO:0060173 limb development ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / reaction / complex
 ENSG00000162337 LRP5 / O75197 / LDL receptor related protein 5  / reaction
 ENSG00000107984 DKK1 / O94907 / dickkopf WNT signaling pathway inhibitor 1  / complex / reaction






 

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