ENSMUSG00000024868


Mus musculus

Features
Gene ID: ENSMUSG00000024868
  
Biological name :Dkk1
  
Synonyms : Dickkopf-related protein 1 / Dkk1 / O54908
  
Possible biological names infered from orthology : dickkopf WNT signaling pathway inhibitor 1 / O94907
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 30545863
Gene end: 30549665
  
Corresponding Affymetrix probe sets: 10467006 (MoGene1.0st)   1420360_at (Mouse Genome 430 2.0 Array)   1458232_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025803
NCBI entrez gene - 13380     See in Manteia.
MGI - MGI:1329040
RefSeq - NM_010051
RefSeq Peptide - NP_034181
swissprot - O54908
Ensembl - ENSMUSG00000024868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dkk1aENSDARG00000014103Danio rerio
 dkk1bENSDARG00000045219Danio rerio
 DKK1ENSGALG00000003814Gallus gallus
 DKK1ENSG00000107984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dkk2 / Q9QYZ8 / Dickkopf-related protein 2 / Q9UBU2* / dickkopf WNT signaling pathway inhibitor 2*ENSMUSG0000002803138
Dkk4 / Q8VEJ3 / Dickkopf-related protein 4 / Q9UBT3* / dickkopf WNT signaling pathway inhibitor 4*ENSMUSG0000003153530


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000904 cell morphogenesis involved in differentiation IMP
 biological_processGO:0001706 endoderm formation IDA
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0001942 hair follicle development IDA
 biological_processGO:0002090 regulation of receptor internalization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007611 learning or memory IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISO
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0030900 forebrain development IGI
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IEA
 biological_processGO:0042663 regulation of endodermal cell fate specification IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IDA
 biological_processGO:0050807 regulation of synapse organization IDA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IDA
 biological_processGO:0060173 limb development IMP
 biological_processGO:0060323 head morphogenesis IGI
 biological_processGO:0060325 face morphogenesis IMP
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0061743 motor learning IDA
 biological_processGO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IGI
 biological_processGO:0090647 modulation of age-related behavioral decline IDA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 biological_processGO:1901296 negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEA
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IDA
 biological_processGO:1904723 negative regulation of Wnt-Frizzled-LRP5/6 complex assembly TAS
 biological_processGO:1904958 positive regulation of midbrain dopaminergic neuron differentiation IMP
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0048019 receptor antagonist activity IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp6Gw/Lrp6+,Wnt3tm1Brd/Wnt3+
Genetic Background: involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * 129/Sv * BALB/c * C3H

Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Dkk1tm1Lmgd/Dkk1+
Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Gsctm2Bhr/Gsctm2Bhr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dkk1tm1Lmgd/Dkk1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Kremen1tm1Dgen/Kremen1tm1Dgen,Kremen2tm1Cni/Kremen2tm1Cni
Genetic Background: either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000568 ectopic digits "positional abnormality of a digit" [J:50311]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6+
Genetic Background: involves: 101/H * 129/Sv * BALB/c * C3H

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Gsctm2Bhr/Gsctm2Bhr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Gsctm2Bhr/Gsc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001678 thick apical ectodermal ridge "increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Dkk1tm1Lmgd/Dkk1+
Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

 MP:0002902 hypophosphaturia "a reduction of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002963 decreased protein excretion "less than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003870 decreased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Lrp6Gw/Lrp6+
Genetic Background: either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)

Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006294 absent optic vesicle "absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Kremen1tm1Dgen/Kremen1tm1Dgen,Kremen2tm1Cni/Kremen2tm1Cni
Genetic Background: either: B6.Cg-Kremen1tm1Dgen Kremen2tm1Cni Dkk1tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0010939 abnormal mandibular prominence morphology 
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic Background: either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl

Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Dkk1tm1Lmgd/Dkk1+
Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011496 abnormal head size "anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [MGI:csmith]
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Allelic Composition: Ctnnb1Bfc/Ctnnb1+,Dkk1tm1Lmgd/Dkk1+,Lrp6Gw/Lrp6+
Genetic Background: either: (involves: 101/H * 129/Sv * BALB/cCrl * C3H) or (involves: 101/H * 129/Sv * BALB/cCrl * C3H * C57BL/6)

Allelic Composition: Ctnnb1Bfc/Ctnnb1Bfc,Dkk1tm1Lmgd/Dkk1+
Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011858 elongated kidney papilla "increased average length of the apex of the renal pyramid that projects into a calyx" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Gsctm2Bhr/Gsc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dkk1tm1Lmgd/Dkk1+,Gsctm2Bhr/Gsctm2Bhr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012178 absent frontonasal prominence "absence of the unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0012517 absent diencephalon "absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MGI:anna]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030324 abnormal anterior head development "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, MGI:anna]
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Allelic Composition: Cdh5tm1Hub/Cdh5tm1Hub
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd,Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic Background: involves: 129 * CD-1

Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex / reaction
 ENSMUSG00000040680 Q8K1S7 / Kremen2 / Kremen protein 2 / Q8NCW0* / kringle containing transmembrane protein 2*  / complex / reaction






 

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