ENSMUSG00000028031


Mus musculus

Features
Gene ID: ENSMUSG00000028031
  
Biological name :Dkk2
  
Synonyms : Dickkopf-related protein 2 / Dkk2 / Q9QYZ8
  
Possible biological names infered from orthology : dickkopf WNT signaling pathway inhibitor 2 / Q9UBU2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 132085292
Gene end: 132180304
  
Corresponding Affymetrix probe sets: 10496125 (MoGene1.0st)   1420512_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029665
NCBI entrez gene - 56811     See in Manteia.
MGI - MGI:1890663
RefSeq - NM_020265
RefSeq - XM_006501818
RefSeq Peptide - NP_064661
swissprot - Q9QYZ8
Ensembl - ENSMUSG00000028031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dkk2ENSDARG00000076420Danio rerio
 DKK2ENSGALG00000028041Gallus gallus
 DKK2ENSG00000155011Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dkk1 / O54908 / Dickkopf-related protein 1 / O94907* / dickkopf WNT signaling pathway inhibitor 1*ENSMUSG0000002486840
Dkk4 / Q8VEJ3 / Dickkopf-related protein 4 / Q9UBT3* / dickkopf WNT signaling pathway inhibitor 4*ENSMUSG0000003153533


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0039706 co-receptor binding IPI


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0013754 abnormal ocular surface morphology "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4]
Show

Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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