ENSG00000155011


Homo sapiens

Features
Gene ID: ENSG00000155011
  
Biological name :DKK2
  
Synonyms : dickkopf WNT signaling pathway inhibitor 2 / DKK2 / Q9UBU2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q25
Gene start: 106921802
Gene end: 107283806
  
Corresponding Affymetrix probe sets: 219908_at (Human Genome U133 Plus 2.0 Array)   224199_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000285311
Ensembl peptide - ENSP00000423797
Ensembl peptide - ENSP00000421255
NCBI entrez gene - 27123     See in Manteia.
OMIM - 605415
RefSeq - NM_014421
RefSeq Peptide - NP_055236
swissprot - D6RGF1
swissprot - D6RCC2
swissprot - Q9UBU2
Ensembl - ENSG00000155011
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dkk2ENSDARG00000076420Danio rerio
 DKK2ENSGALG00000028041Gallus gallus
 Dkk2ENSMUSG00000028031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DKK1 / O94907 / dickkopf WNT signaling pathway inhibitor 1ENSG0000010798439
DKK4 / Q9UBT3 / dickkopf WNT signaling pathway inhibitor 4ENSG0000010437132


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway NAS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway NAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 molecular_functionGO:0039706 co-receptor binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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