ENSG00000104371


Homo sapiens

Features
Gene ID: ENSG00000104371
  
Biological name :DKK4
  
Synonyms : dickkopf WNT signaling pathway inhibitor 4 / DKK4 / Q9UBT3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.21
Gene start: 42374068
Gene end: 42377232
  
Corresponding Affymetrix probe sets: 206619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000220812
NCBI entrez gene - 27121     See in Manteia.
OMIM - 605417
RefSeq - XM_017013316
RefSeq - NM_014420
RefSeq - XM_011544488
RefSeq Peptide - NP_055235
swissprot - Q9UBT3
Ensembl - ENSG00000104371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Dkk4ENSMUSG00000031535Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DKK2 / Q9UBU2 / dickkopf WNT signaling pathway inhibitor 2ENSG0000015501137
DKK1 / O94907 / dickkopf WNT signaling pathway inhibitor 1ENSG0000010798435


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich
 IPR023569  Prokineticin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0061170 negative regulation of hair follicle placode formation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway NAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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