ENSMUSG00000031535


Mus musculus

Features
Gene ID: ENSMUSG00000031535
  
Biological name :Dkk4
  
Synonyms : Dickkopf-related protein 4 / Dkk4 / Q8VEJ3
  
Possible biological names infered from orthology : dickkopf WNT signaling pathway inhibitor 4 / Q9UBT3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 22624043
Gene end: 22627547
  
Corresponding Affymetrix probe sets: 10570850 (MoGene1.0st)   1425447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033936
NCBI entrez gene - 234130     See in Manteia.
MGI - MGI:2385299
RefSeq - NM_145592
RefSeq - XM_006509098
RefSeq Peptide - NP_663567
swissprot - Q8VEJ3
Ensembl - ENSMUSG00000031535
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DKK4ENSG00000104371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dkk2 / Q9QYZ8 / Dickkopf-related protein 2 / Q9UBU2* / dickkopf WNT signaling pathway inhibitor 2*ENSMUSG0000002803138
Dkk1 / O54908 / Dickkopf-related protein 1 / O94907* / dickkopf WNT signaling pathway inhibitor 1*ENSMUSG0000002486837


Protein motifs (from Interpro)
Interpro ID Name
 IPR006796  Dickkopf, N-terminal cysteine-rich
 IPR023569  Prokineticin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0061170 negative regulation of hair follicle placode formation IDA
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1.1Vlcg/Dicer1tm2.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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