ENSMUSG00000040901


Mus musculus

Features
Gene ID: ENSMUSG00000040901
  
Biological name :Kcnk18
  
Synonyms : Kcnk18 / Potassium channel subfamily K member 18 / Q6VV64
  
Possible biological names infered from orthology : potassium two pore domain channel subfamily K member 18 / Q7Z418
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D3
Gene start: 59219648
Gene end: 59237370
  
Corresponding Affymetrix probe sets: 10464365 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000065713
NCBI entrez gene - 332396     See in Manteia.
MGI - MGI:2685627
RefSeq - NM_207261
RefSeq Peptide - NP_997144
swissprot - Q6VV64
Ensembl - ENSMUSG00000040901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnk18ENSDARG00000057049Danio rerio
 KCNK18ENSGALG00000009265Gallus gallus
 KCNK18ENSG00000186795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport ISO
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0071435 potassium ion export IEA
 biological_processGO:0071467 cellular response to pH IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015269 calcium-activated potassium channel activity IDA
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA
 molecular_functionGO:0022841 potassium ion leak channel activity IBA


Pathways (from Reactome)
Pathway description
TWIK-related spinal cord K+ channel (TRESK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-Clo/KitlSl-Clo
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040901 Kcnk18 / Q6VV64 / Potassium channel subfamily K member 18 / Q7Z418* / potassium two pore domain channel subfamily K member 18*  / complex






 

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